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extracellular matrix

Modulation of Immune-Inflammatory Responses through Surface Modifications of Biomaterials to Promote Bone Healing and Regeneration

[Journal of Tissue Engineering] Scientists present various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.

miRNA-200c-3p Targets Talin-1 to Regulate Integrin-Mediated Cell Adhesion

[Scientific Reports] Overexpression of miR-200c-3p resulted in a remarkable decrease in the expression of TLN1, which was associated with the suppression of integrin-mediated cell adhesion to fibronectin.

Tumor DDR1 Promotes Collagen Fibre Alignment to Instigate Immune Exclusion

[Nature] Researchers showed that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity, instigated immune exclusion by promoting collagen fiber alignment.

Hypoxia Induces Stress Fiber Formation in Adipocytes in the Early Stage of Obesity

[Scientific Reports] Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.

Extracellular LGALS3BP Regulates Neural Progenitor Position and Relates to Human Cortical Complexity

[Nature Communications] Single-cell RNA-sequencing and proteomics reveal that LGALS3BP-mediated mechanisms involved the ECM in neural progenitor cells’ anchoring and migration within the human brain.

T1ρ Imaging as a Non-Invasive Assessment of Collagen Remodeling and Organization in Human Skeletal Muscle after Ligamentous Injury

[Journal of Physiology] Researchers evaluated the potential of a magnetic resonance imaging sequence that quantified T1ρ relaxation time to predict extracellular matrix collagen composition and organization.

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