Tag results:
extracellular matrix
Immune Regulation News
Modulation of Immune-Inflammatory Responses through Surface Modifications of Biomaterials to Promote Bone Healing and Regeneration
[Journal of Tissue Engineering] Scientists present various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.
Extracellular Matrix News
miRNA-200c-3p Targets Talin-1 to Regulate Integrin-Mediated Cell Adhesion
[Scientific Reports] Overexpression of miR-200c-3p resulted in a remarkable decrease in the expression of TLN1, which was associated with the suppression of integrin-mediated cell adhesion to fibronectin.
Extracellular Matrix News
Tumor DDR1 Promotes Collagen Fibre Alignment to Instigate Immune Exclusion
[Nature] Researchers showed that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity, instigated immune exclusion by promoting collagen fiber alignment.
Extracellular Matrix News
Hypoxia Induces Stress Fiber Formation in Adipocytes in the Early Stage of Obesity
[Scientific Reports] Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.
Extracellular Matrix News
Extracellular LGALS3BP Regulates Neural Progenitor Position and Relates to Human Cortical Complexity
[Nature Communications] Single-cell RNA-sequencing and proteomics reveal that LGALS3BP-mediated mechanisms involved the ECM in neural progenitor cells’ anchoring and migration within the human brain.
Muscle Cell News
T1ρ Imaging as a Non-Invasive Assessment of Collagen Remodeling and Organization in Human Skeletal Muscle after Ligamentous Injury
[Journal of Physiology] Researchers evaluated the potential of a magnetic resonance imaging sequence that quantified T1ρ relaxation time to predict extracellular matrix collagen composition and organization.