extracellular matrix

[Scientific Reports] To understand the interplay between cardiomyocyte and nonmyocyte cell types in human hypertrophic cardiomyopathy (HCM), single nuclei RNA-sequencing was performed on myectomy specimens from HCM patients with left ventricular outflow tract obstruction and control samples from donor hearts free of cardiovascular disease.

[Scientific Reports] Researchers investigated the effect of an oxidized nanocrystalline diamond coating functionalized with bone morphogenetic protein 7 (BMP-7) on human osteoblast maturation and ECM mineralization in vitro and on new bone formation in vivo.

[Matrix Biology] Scientists defined type III Collagen as a suppressor of scar formation and desmoplasia through its effects, in part, on myofibroblasts.

[Seminars in Cell & Developmental Biology] The authors describe the plasticity of dermal fibroblasts (dFBs) during development and wound healing and how various dFB-derived extracellular matrix (ECM) molecules, and in turn how these ECM molecules play a role in regulating the function of dFBs and immune cells.

[Seminars in Cancer Biology] The authors summarize the current knowledge around the effects of chemotherapy on both ECM remodeling and ECM-cell signaling and discuss the implications of these alterations on distinct mechanisms of chemoresistance.

[Journal of Hematology & Oncology] Investigators summarize recent work on the regulation of ECM stiffness in cancer and the effects of ECM stiffness on tumor progression, cancer immunity, and drug resistance.