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extracellular matrix

Orthogonally Induced Differentiation of Stem Cells for the Programmatic Patterning of Vascularized Organoids and Bioprinted Tissues

[Nature Biomedical Engineering] Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.

UVB-Mediated DNA Damage Induces Matrix Metalloproteinases to Promote Photoaging in an AhR- and SP1-Dependent Manner

[JCI Insight] Investigators showed that matrix metalloproteinase 2, which degrades type IV collagen, was abundantly expressed in human skin, increased with age in sun-exposed skin, and correlated robustly with aryl hydrocarbon receptor (AhR), a transcription factor directly activated by UV-generated photometabolites.

A Negative Feedback Loop between Fibroadipogenic Progenitors and Muscle Fibers Involving Endothelin Promotes Human Muscle Fibrosis

[Journal of Cachexia Sarcopenia and Muscle] The authors demonstrated the key role of fibroadipogenic progenitors and their cross-talk with muscle cells through a paracrine signaling pathway in fibrosis of human skeletal muscle and identified endothelin as a new druggable target to counteract human muscle fibrosis.

A Genome-Wide Meta-Analysis Identifies 50 Genetic Loci Associated with Carpal Tunnel Syndrome

[Nature Communications] Through various functional analyses, researchers concluded that at least 22 genes mediated carpal tunnel syndrome (CTS) risk and highlighted the role of 19 CTS variants in the biology of the ECM.

Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids

[Advanced Science] Investigators developed in vitro methods using a kidney decellularized ECM hydrogel to culture human pluripotent stem cell-derived kidney organoids, which had extensive vascular network and their own endothelial cells.

Development of a Cell-Free Strategy to Recover Aged Skeletal Muscle after Disuse

[Journal of Physiology] Single-cell RNA sequencing and functional assays were performed to demonstrate that pericytes in mouse skeletal muscle lost the capacity to synthesize antioxidants during disuse and recovery.

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