extracellular matrix

[Biomacromolecules] Scientists presented two series of fibrous and porous hydrogels and used them as substrates to study the mechanoresponses of bone marrow MSCs to stiffness and fibrous structure.

[iScience] The authors found that lysophosphatidic acid induced the differentiation of a previously unsuspected keratinocyte subpopulation expressing the extracellular matrix protein, thrombospondin-1 (THBS1).

[Signal Transduction and Targeted Therapy] Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] The authors addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle-incorporated porcine cholecystic ECM for the same.

[Translational Oncology] Researchers performed a label-free proteomic analysis of exosomes from a pair of homologous human colorectal cancer cell line with different metastatic abilities.

[iScience] Investigators revealed the mechanism responsible for the dilated ER that is a hallmark characteristic of osteosarcomas and identified a highly conserved molecular signature for this genetically unstable tumor.