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fibroblasts

Quercetin Promotes Cutaneous Wound Healing in Mice through Wnt/β-Catenin Signaling Pathway

[Journal of Ethnopharmacology] Researchers evaluated the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and revealed the Wnt/β-catenin pathway and telomerase reverse transcriptase involved mechanisms.

Cardiac Fibroblasts Secrete Exosome microRNA to Suppress Cardiomyocyte Pyroptosis in Myocardial Ischemia/Reperfusion Injury

[Molecular and Cellular Biochemistry] Scientists showed that cardiac fibroblasts protected cardiomyocytes against myocardial ischemia/reperfusion-induced injury through suppression of pyroptosis.

Irreversibility of Pulmonary Fibrosis

[Aging and Disease] The authors discuss the underlying pathogenesis of irreversible pulmonary fibrosis as well as preclinical disease models, and also suggest directions for future studies.

TNF Antagonist Sensitizes Synovial Fibroblasts to Ferroptotic Cell Death in Collagen-Induced Arthritis Mouse Models

[Nature Communications] Scientists showed, using a collagen-induced arthritis mouse model, that imidazole ketone erastin, a ferroptosis inducer, decreased fibroblast numbers in the synovium.

Inflammatory Fibroblasts Mediate Resistance to Neoadjuvant Therapy in Rectal Cancer

[Cancer Cell] Investigators showed that, upon irradiation, interleukin-1α (IL-1α) not only polarized cancer-associated fibroblasts (CAFs) toward the inflammatory phenotype but also triggered oxidative DNA damage, thereby predisposing inflammatory CAFs to p53-mediated therapy-induced senescence, which in turn resulted in chemoradiotherapy resistance and disease progression.

Tick Tock, Tick Tock: Mouse Culture and Tissue Aging Captured by an Epigenetic Clock

[Aging Cell] By developing a measure that tracked cellular aging in vitro, we tested whether it tracked physiological aging in various mouse tissues and whether anti-aging interventions modulate this measure.

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