fibroblasts

[Arthritis & Rheumatology] Researchers examined whether the inhibition of cell cycle with cyclin-dependent kinase (CDK) 4/6 inhibitor suppressed fibroblast proliferation and the differentiation into myofibroblasts, and the therapeutic effect of a CDK4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis in monotherapy or in combination with TGF-β receptor inhibitor.

[Experimental Dermatology] In the skin, UV-irradiation increases expression of matrix metalloproteinases (MMPs) that causes dysregulation of extracellular matrix homeostasis in dermis, leading to acceleration of skin aging. Researchers reported the role of transglutaminase 2 in mediating the UVB-induced expression of MMP-1.

[Journal of Controlled Release] Researchers developed an advanced three-dimensional in vitro intestinal model to test absorption in a more reliable manner, by better mimicking the native environment.

[JCI Insight] Scientists identified the senescence-like characteristics of cancer-associated fibroblasts (CAFs) after RT and clarify the formidable ability of senescence-like CAFs in promoting NSCLC cell proliferation and radioresistance through the JAK/STAT pathway.

[Stem Cell Research] The authors generated an iPSC line from the skin fibroblasts collected from a healthy 50-year old male donor. This model that could be used to model physiological processes and screen drug validation in vitro.

[Cold Spring Harbor Perspectives in Biology] Investigators found a set of four defined factors that could reprogram fibroblasts into iPSCs, which were shown to be molecularly and functionally equivalent to blastocyst-derived ESCs, thus essentially showing that defined factors could induce authentic reprogramming without the need of oocytes.