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fibroblasts

A Deep Learning Approach to Identify and Segment Alpha-Smooth Muscle Actin Stress Fiber Positive Cells

[Scientific Reports] Researchers presented a computer vision model to classify and segmented cells containing alpha-smooth muscle actin stress fibers into two classes, with a high degree of accuracy.

Human Endothelial Cells and Fibroblasts Express and Produce the Coagulation Proteins Necessary for Thrombin Generation

[Scientific Reports] Researchers described experiments that detail the expression and production in endothelial cells (EC) and fibroblasts of the clotting proteins necessary for formation of active prothrombinase complexes to produce thrombin on EC and fibroblast surfaces.

Cancer-Associated Fibroblasts-Derived HAPLN1 Promotes Tumour Invasion through Extracellular Matrix Remodeling in Gastric Cancer

[Gastric Cancer] SHG assays with mouse xenograft models and human samples demonstrated cancer-associated fibroblasts-derived hyaluronan and proteoglycan link protein 1 (HAPLN1) increased tumour invasiveness through ECM remodeling.

Human Umbilical Cord-Mesenchymal Stem Cells Survive and Migrate within the Vitreous Cavity and Ameliorate Retinal Damage in a Novel Rat Model of Chronic Glaucoma

[Stem Cells International] Scientists investigated the ability of transplanted human umbilical cord-mesenchymal stem cell to survive and migrate within the vitreous cavity and their neuroprotective effects on chronic glaucomatous retina.

Sensitization of the UPR by Loss of PPP1R15A Promotes Fibrosis and Senescence in IPF

[Scientific Reports] Researchers demonstrated the major role of PPP1R15A in the regulation of lung mesenchymal cells, and regulation of PPP1R15A may represent a novel therapeutic strategy in idiopathic pulmonary fibrosis.

Hypoxia Induces Stress Fiber Formation in Adipocytes in the Early Stage of Obesity

[Scientific Reports] Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.

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