fibroblasts

[Nature] Using a non-human primate model of lung injury, together with human organoids and tissue specimens, researchers showed that alveolar type-2 cells in regenerating lungs transiently acquire an alveolar type-0 state from which they can differentiate into either alveolar type-1 cells or respiratory bronchiole-secretory cells.

[Nature Biomedical Engineering] Investigators generated chemically induced cardiovascular progenitor cells self-renewed long-term in fully chemically defined and xeno-free conditions, with faithful preservation of the cardiovascular progenitor cell phenotype and of cardiovascular differentiation capacity in vitro and in vivo.

[Scientific Reports] The authors described a novel subset of renal perivascular MSCs that expressed Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair.

[Dental Materials] Researchers analyzed the formation of the pro-inflammatory cytokines TNFα and IL-6 in lipopolysaccharide (LPS)- or lipoteichoic acid (LTA)-stimulated cells from the dental pulp interface and pulp fibroblasts in the presence of the resin monomer 2-hydroxyethyl methacrylate (HEMA).

[Scientific Reports] To understand the interplay between cardiomyocyte and nonmyocyte cell types in human hypertrophic cardiomyopathy (HCM), single nuclei RNA-sequencing was performed on myectomy specimens from HCM patients with left ventricular outflow tract obstruction and control samples from donor hearts free of cardiovascular disease.

[Matrix Biology] Scientists defined type III Collagen as a suppressor of scar formation and desmoplasia through its effects, in part, on myofibroblasts.