Antitumor Effect of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-Ol in Combination with Target Therapy in Melanoma Models

When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis.
[Cell Death Discovery]
Di Martile, M., Garzoli, S., Sabatino, M., Valentini, E., D’Aguanno, S., Ragno, R., & Del Bufalo, D. (2021). Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00510-3 Cite
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Distinct Fibroblasts in Scars and Regeneration

The authors discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin’s wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration.
[Current Opinion in Genetics & Development]
Distinct fibroblasts in scars and regeneration. (2021). Current Opinion in Genetics & Development, 70, 7–14. https://doi.org/10.1016/j.gde.2021.04.005 Cite
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Identification of Hepatic Fibrosis Inhibitors through Morphometry Analysis of a Hepatic Multicellular Spheroids Model

Scientists established liver fibrosis models using multicellular tumor spheroids (MCTSs) composed of hepatocellular carcinoma (HCC) and stromal cells such as fibroblasts (WI38), hepatic stellate cells (LX2), and endothelial cells (HUVEC) seeded at constant ratios.
[Scientific Reports]
Song, Y., Kim, S., Heo, J., Shum, D., Lee, S.-Y., Lee, M., Kim, A.-R., & Seo, H. R. (2021). Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model. Scientific Reports, 11(1), 10931. https://doi.org/10.1038/s41598-021-90263-x Cite
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Orphan Nuclear Receptor COUP-TFII Enhances Myofibroblast Glycolysis Leading to Kidney Fibrosis

Scientists found increased COUP-TFII expression in myofibroblasts in human fibrotic kidneys, lungs, kidney organoids, and mouse kidneys after injury.
[EMBO Reports]
Li, L., Galichon, P., Xiao, X., Figueroa-Ramirez, A. C., Tamayo, D., Lee, J. J.-K., Kalocsay, M., Gonzalez-Sanchez, D., Chancay, M. S., McCracken, K. W., Lee, N. N., Ichimura, T., Mori, Y., Valerius, M. T., Wilflingseder, J., Lemos, D. R., Edelman, E. R., & Bonventre, J. V. (2021). Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Reports, n/a(n/a), e51169. https://doi.org/10.15252/embr.202051169 Cite
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Characterization of the Heterogeneity of Endothelial Cells in Bleomycin-Induced Lung Fibrosis Using Single-Cell RNA Sequencing

Scientists performed single-cell RNA sequencing to characterize the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis in rats.
[Angiogenesis]
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COVID-19 and Pulmonary Fibrosis: A Potential Role for Lung Epithelial Cells and Fibroblasts

The disease ranges in severity from asymptomatic through to severe acute respiratory distress requiring intensive care treatment and mechanical ventilation, which can lead to respiratory failure and death.
[Immunological Reviews]
John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (n.d.). COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts. Immunological Reviews, n/a(n/a). https://doi.org/https://doi.org/10.1111/imr.12977 Cite
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Simplification of Culture Conditions and Feeder-Free Expansion of Bovine Embryonic Stem Cells

Simplified conditions will facilitate the use of bovine ESCs for gene editing applications and pluripotency and lineage commitment studies.
[Scientific Reports]
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MiR-124 Synergism with ELAVL3 Enhances Target Gene Expression to Promote Neuronal Maturity

Here, we identified targets of miR-9/9*-124 as reprogramming cells activate the neuronal program and reveal the role of miR-124 that directly promotes the expression of its target genes associated with neuronal development and function.
[Proceedings of the National Academy of Sciences of the United States of America]
Lu, Y.-L., Liu, Y., McCoy, M. J., & Yoo, A. S. (2021). MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proceedings of the National Academy of Sciences, 118(22). https://doi.org/10.1073/pnas.2015454118 Cite
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Metalloproteinase 1 Downregulation in Neurofibromatosis 1: Therapeutic Potential of Antimalarial Hydroxychloroquine and Chloroquine

Researchers analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.
[Cell Death & Disease]
Tsuji, G., Takai-Yumine, A., Kato, T., & Furue, M. (2021). Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine. Cell Death & Disease, 12(6), 1–11. https://doi.org/10.1038/s41419-021-03802-9 Cite
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Transthyretin Amyloid Fibrils Alter Primary Fibroblast Structure, Function and Inflammatory Gene Expression

Investigators suggested that transthyretin deposited in tissue extracellular matrix may affect both the structure, function and gene expression of cardiac fibroblasts.
[American Journal of Physiology-Heart and Circulatory Physiology]
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Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

Researchers investigated sex-based differences in the molecular mechanisms of anticancer immune-response and immune evasion in patients with non-small cell lung cancer.
[Clinical Cancer Research]
Conforti, F., Pala, L., Pagan, E., Bagnardi, V., Pas, T. D., Queirolo, P., Pennacchioli, E., Catania, C., Cocorocchio, E., Ferrucci, P. F., Saponara, M., Orsolini, G., Zagami, P., Nicolo, E., Marinis, F. D., Tortora, G., Bria, E., Minucci, S., Joffe, H., … Giaccone, G. (2021). Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0136 Cite
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