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fibroblasts

Targeting of the Tumor Immune Microenvironment by Metformin

[Journal of Cell Communication and Signaling] The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.

Metformin and Sodium Dichloroacetate Effects on Proliferation, Apoptosis, and Metabolic Activity Tested Alone and in Combination in a Canine Prostate and a Bladder Cancer...

[PLOS ONE] Researchers evaluated the independent and synergistic effect of metformin and sodium dichloroacetate on the metabolic activity, cell proliferation, and apoptosis of a canine prostate adenocarcinoma and a transitional cell carcinoma cell line in comparison to a primary canine fibroblast culture.

Three Subtypes of Lung Cancer Fibroblasts Define Distinct Therapeutic Paradigms

[Cancer Cell] By functionally interrogating cancer-associated fibroblasts heterogeneity using the same therapeutics received by patients, the authors identified three functional subtypes: robustly protective of cancers and highly expressing HGF and FGF7; moderately protective of cancers and highly expressing FGF7; and those providing minimal protection.

Matrix Stiffness Drives Stromal Autophagy and Promotes Formation of a Protumorigenic Niche

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that an increased physical rigidity of a fibroblast’s environment was sufficient to evoke stromal autophagy. Mechanistically, matrix stiffness was transmitted via Integrin αV receptors and focal adhesion kinase, resulting in stabilization of AMPK at focal adhesion structures.

The Interaction of Helicobacter pylori with Cancer Immunomodulatory Stromal Cells: New Insight into Gastric Cancer Pathogenesis

[Seminars in Cancer Biology] The authors discuss the interplay between H. pylori and tumor-supportive cells, including mesenchymal stem cells, cancer-associated fibroblasts, tumor-associated macrophages, and myeloid derived-suppressor cells in gastric cancer.

ATP-Citrate Lyase Promotes Axonal Transport across Species

[Nature Communications] Researchers showed that Acly expression was reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species.

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