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fibroblasts

ZNF545 Loss Promotes Ribosome Biogenesis and Protein Translation to Initiate Colorectal Tumorigenesis in Mice

[Oncogene] The authors investigated the functional and molecular mechanism of Zinc finger protein 545 (ZNF545), a transcriptional repressor for ribosomal RNA, in colorectal cancer (CRC). ZNF545 was silenced in CRC compared to adjacent normal tissues, implying a tumor-suppressive role.

A Human iPSC-Derived Inducible Neuronal Model of Niemann-Pick Disease, Type C1

[BMC Biology] Investigators reported the development of a novel human iPSC-derived, inducible neuronal model of Niemann-Pick disease, type C1, and demonstrated the utility of this new cell line in high-throughput drug/chemical screens to identify potential therapeutic agents.

The Extracellular Matrix Glycoprotein ADAMTSL2 Is Increased in Heart Failure and Inhibits TGFβ Signaling in Cardiac Fibroblasts

[Scientific Reports] The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts

Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice

[Developmental Cell] Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.

Suppression of Autophagy Promotes Fibroblast Activation in p53-Deficient Colorectal Cancer Cells

[Scientific Reports] Researchers aimed to clarify the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines in vitro.

Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation...

[Oncology Reports] The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigenesis.

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