Tag results:
fibroblasts
Intestinal Cell News
ZNF545 Loss Promotes Ribosome Biogenesis and Protein Translation to Initiate Colorectal Tumorigenesis in Mice
[Oncogene] The authors investigated the functional and molecular mechanism of Zinc finger protein 545 (ZNF545), a transcriptional repressor for ribosomal RNA, in colorectal cancer (CRC). ZNF545 was silenced in CRC compared to adjacent normal tissues, implying a tumor-suppressive role.
ESC & iPSC News
A Human iPSC-Derived Inducible Neuronal Model of Niemann-Pick Disease, Type C1
[BMC Biology] Investigators reported the development of a novel human iPSC-derived, inducible neuronal model of Niemann-Pick disease, type C1, and demonstrated the utility of this new cell line in high-throughput drug/chemical screens to identify potential therapeutic agents.
Extracellular Matrix News
The Extracellular Matrix Glycoprotein ADAMTSL2 Is Increased in Heart Failure and Inhibits TGFβ Signaling in Cardiac Fibroblasts
[Scientific Reports] The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts
Dermal Cell News
Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice
[Developmental Cell] Investigators found that following traumatic injury to ear pinnae, myofibroblasts appeared rapidly in both Acomys and mouse yet persisted only in mouse.
Intestinal Cell News
Suppression of Autophagy Promotes Fibroblast Activation in p53-Deficient Colorectal Cancer Cells
[Scientific Reports] Researchers aimed to clarify the significance of autophagy in fibroblasts, focusing on the TP53 status in co-cultured human colorectal cancer cell lines in vitro.
Cancer Stem Cell News
Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation...
[Oncology Reports] The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigenesis.