fibroblasts

[iScience] The authors reported that myofibroblasts expressed and secreted PKM2. Extracellular PKM2 upregulated arginase-1 expression in myofibroblasts, therefore facilitating proline biosynthesis and subsequent collagen production.

[International Wound Journal] Investigators constructed a cell model of hypertrophic scar (HTs) and explored the role of Nesprin-2 in this process. Myofibroblasts and fibroblasts were isolated from HTs and healthy skin tissues of the same patient.

[Aging-Us] The authors found that conditioned medium harvested from WI-38 lung fibroblasts and H1299 lung adenocarcinoma cells exposed to 0.1Gy to 1Gy could enhance the migration and invasion of unirradiated H1299 cells in both 2D and 3D culturing circumstances.

[Cancer Research] Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.

[Stem Cell Research & Therapy] Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.

[Cell Death & Disease] Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.