The authors demonstrated that fibroblasts reduced lapatinib sensitivity in a subset of HER2+ breast cancer cells via paracrine signaling that could be reversed by targeting downstream survival programs such as MTOR and antiapoptotic proteins.
[Proceedings of the National Academy of Sciences of the United States of America]
Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]
Investigators showed that the profibrotic actions of TGF‐β were mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 reversed pulmonary fibrosis.
Investigators provide a comprehensive characterization of the developmental expression profile of multiple microRNAs during epicardial development in chicken. They identified that miR-125, miR-146, miR-195 and miR-223 selectively enhanced cardiomyogenesis both in the proepicardium/ST explants as well as in the embryonic epicardium, a Smurf1- and Foxp1-driven process.
The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
The authors provided mechanistic insight into the roles of activin in wound repair and fibrosis and identified the functional consequences of alterations in the wound matrisome at the biomechanical level.