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flow cytometry

Targeting CD33 for Acute Myeloid Leukemia Therapy

[BMC Cancer] Investigators analyzed the level of CD33 expression in patients with newly diagnosed acute myeloid leukemia and determined its correlation with clinical characteristics. Of the 86 patients, CD33-high was closely related to the patients with normal karyotype, high white blood cell count, and a high ratio of primitive cells.

Hsa_circ_0074298 Promotes Pancreatic Cancer Progression and Resistance to Gemcitabine by Sponging miR-519 to Target SMOC

[Journal of Cancer] Scientists investigate the expression of hsa_circ_0074298 and the molecular mechanism that promoted tumor growth and enhanced the chemoresistance of pancreatic cancer.

Intermittent Compressive Force Induces Cell Cycling and Reduces Apoptosis in Embryoid Bodies of Mouse Induced Pluripotent Stem Cells

[International Journal of Oral Science] Scientists identified a molecular mechanism in iPSCs responding to intermittent compressive force by analyzing the global gene expression profile.

Hypoxia-Induced Fascin-1 Upregulation Is Regulated by Akt/Rac1 Axis and Enhances Malignant Properties of Liver Cancer Cells via Mediating Actin Cytoskeleton Rearrangement and Hippo/Yap Activation

[Cell Death Discovery] Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.

Silencing of circDPP4 Suppresses Cell Progression of Human Prostate Cancer and Enhances Docetaxel Cytotoxicity through Regulating miR-564/ZIC2 Axis

[Journal of Gene Medicine] Expression of circular RNA derived from dipeptidyl peptidase 4 (circDPP4) was upregulated in prostate cancer (PC) tumors from 60 patients and PC cell lines, and higher circDPP4 might predict poor overall survival. Decreasing circDPP4 suppresses cell proliferation, colony formation, migration/invasion, and 50% inhibitory concentration of docetaxel in PC cells.

Co-Administration of Human MSC Overexpressing HIF-1α Increases Human CD34+ Cell Engraftment In Vivo

[Stem Cell Research & Therapy] Human cord blood CD34+ cells were co-cultured with mesenchymal stromal cells (MSC) wild type or Hypoxia-inducible factor-1α-MSC (4:1) for 72 hours. Then, viability, cell cycle, ROS expression and immunophenotyping of key molecules involved in engraftment were evaluated by flow cytometry in CD34+ cells.

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