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flow cytometry

Expression of Hv1 Proton Channels in Myeloid-Derived Suppressor Cells (MDSC) and Its Potential Role in T Cell Regulation

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that mouse MDSCs expressed functional Hv1 proton channels by immunofluorescence microscopy, flow cytometry, and Western blot, besides performing a biophysical characterization of its macroscopic currents via patch-clamp technique.

A Synthesized Olean-28,13β-Lactam Targets YTHDF1-GLS1 Axis to Induce ROS-Dependent Metabolic Crisis and Cell Death in Pancreatic Adenocarcinoma

[Cancer Cell International] Researchers evaluated and confirmed the promising anti-tumor activity of olean-28,13β-lactam (B28) in vitro. RNA-seq profile indicated that multiple metabolic pathways were interrupted in B28 treated pancreatic adenocarcinoma cells.

Monocyte Subpopulation Profiling Indicates CDK6-Derived Cell Differentiation and Identifies Subpopulation-Specific miRNA Expression Sets in Acute and Stable Coronary Artery Disease

[Scientific Reports] Investigators characterized monocyte subsets in controls and disease phenotypes of coronary artery disease and mmyocardial infarction patients using flow cytometry and miRNA and mRNA expression profiling using RNA sequencing.

Small Molecules Facilitate Single Factor-Mediated Sweat Gland Cell Reprogramming

[Military Medical Research] Investigators developed a stepwise reprogramming strategy to convert fibroblasts into sweat gland lineages, which may provide a promising method to obtain desirable cell types for the functional repair and regeneration of damaged skin.

The Isoflavanoid (+)-PTC Regulates Cell-Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line

[Chemistry & Biodiversity] Scientists evaluated, using flow cytometry, confocal microscopy and image analysis, the anti-proliferative effects of (+)-2,3,9-trimethoxypterocarpan on relevant human prostate cancer cells as well as its capacity to control mitosis within them.

Heterogeneous Nuclear Ribonucleoprotein K Promotes the Progression of Lung Cancer by Inhibiting the p53-Dependent Signaling Pathway

[Thoracic Cancer] Inhibition of progression of lung cancer cells induced by heterogeneous nuclear ribonucleoprotein K-knockdown was dependent on activation of p53 by the p53/p21/cyclin D1 pathway.

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