Antigen Multimers: Specific, Sensitive, Precise, and Multifunctional High-Avidity CAR-Staining Reagents

Investigators developed tetrameric and dodecameric forms of a multifunctional and extensible category of high-avidity CAR-staining reagents: antigen multimers.
[Matter]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

A Novel CD34-Derived Hinge for Rapid and Efficient Detection and Enrichment of CAR T-cells

For establishing a novel hinge derived from human CD34, researchers systematically tested CD34 fragments of different lengths, all containing the binding site of the QBend-10 monoclonal antibody, in a FMC63-based CD19 CAR lentiviral construct.
[Molecular Therapy-Oncolytics]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

MicroRNA-155-5p Initiates Childhood Acute Lymphoblastic Leukemia by Regulating the IRF4/CDK6/CBL Axis

Scientists explored putative mechanisms of microRNA-155-5p involvement in childhood acute lymphoblastic leukemia via interactions with casitas B-lineage lymphoma (CBL), interferon regulatory factor 4 (IRF4), and cyclin-dependent kinase 6 (CDK6).
[Laboratory Investigation]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

A Method for Rapid Flow-Cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

Scientists developed an approach to examine endothelial RNA expression by using an endothelial-specific marker to isolate nuclei from abundant archived frozen brain tissues.
[Laboratory Investigation]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Circ_0057583 Facilitates Brain Microvascular Endothelial Cell Injury through Modulating miR-204-5p/NR4A1 Axis

Investigators explored the potential role and mechanism of circ_0057583 in brain microvascular endothelial cell injury. Human brain microvascular endothelial cells were exposed to different doses of lipopolysaccharide to induce cell damage.
[Metabolic Brain Disease]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

ROR2 Has a Protective Role in Melanoma by Inhibiting Akt Activity, Cell-Cycle Progression, and Proliferation

The role of Receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.
[Journal of Biomedical Science]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Genetically Modified Mesenchymal Stem Cells Promote Spinal Fusion through Polarized Macrophages

MSCs were genetically modified to overexpress placental growth factor, and its effects on macrophage proliferation and polarization were analyzed in vitro in a transwell co-culture system, as well as in vivo in a mouse model for spinal fusion, for which the cells were bilaterally injected into paravertebral muscles of the mouse lumbar spine.
[Laboratory Investigation]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Generation of Heart-Forming Organoids from Human Pluripotent Stem Cells

Researchers provided a detailed protocol describing how to form heart-forming organoids within 14 days, that could be used on many different human PSC lines and be combined with manipulation technologies such as gene targeting and drug testing.
[Nature Protocols]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Silencing Akt1 Enhances the Resistance of Prostate Cancer Cells to Starvation and Inhibits Starvation-Induced Lung Metastasis through Epithelial–Mesenchymal Transition in Prostate Cancer

Scientists reported that although silencing Akt1 enhanced the invasion of prostate cancer (PCa) cells induced by nutritional starvation (NST) in vitro, silencing Akt1 inhibited the PCa lung metastasis induced by NST in vivo.
[Medical Oncology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

miR-126 in Extracellular Vesicles Derived from Hepatoblastoma Cells Promotes the Tumorigenesis of Hepatoblastoma through Inducing the Differentiation of BMSCs into Cancer Stem Cells

Scientists explored the differentially expressed miRNAs related to tumor cell-derived extracellular vesciles (EVs) and the mechanism by which EVs regulated hepatoblastoma progression.
[Journal of Immunology Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

MicroRNA-200c/429 Mediated Regulation of Zeb1 Augments N-cadherin in Mouse Cardiac Mesenchymal Cells

Scientists investigated the expression of N-Cadherin, a trans-membrane protein that enhanced the cell adhesion and recently gained attention for differentiation and augmentation of stem cell function, in mouse cardiac MSCs.
[Cell Biology International]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share