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flow cytometry

Ubiquitin-Specific Protease 1 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Doxorubicin by Ubiquitinated Proliferating Cell Nuclear Antigen–Mediated Attenuation of Stemness

[Anti-Cancer Drugs] Scientists investigate the effect of Ubiquitin-specific protease 1 (USP1) depletion with chemotherapeutant doxorubicin on the hepatocellular carcinoma cells.

Efficient Isolation of Human Gingival Stem Cells in a New Serum-Free Medium Supplemented with Platelet Lysate and Growth Hormone for Osteogenic Differentiation Enhancement

[Stem Cell Research & Therapy] Gingival stem cell isolation and thawing under these conditions were successful, and no significant DNA lesions were detected.

CD4+ T Cell Dysfunction in Severe COVID-19 Disease is TNFα/TNFRI-Dependent

[American Journal of Respiratory and Critical Care Medicine] Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.

Pirfenidone Exacerbates Th2-Driven Vasculopathy in a Mouse Model of SSc-ILD

[European Respiratory Journal] Pirfenidone treatment attenuated pulmonary remodelling in the bleomycin-model, but aggravated pulmonary inflammation, fibrosis, and vascular remodelling in Fra-2 TG mice.

Downregulation of lncRNA NEAT1 Relieves Caerulein-Induced Cell Apoptosis and Inflammatory Injury in AR42J Cells through Sponging MiR-365a-3p in Acute Pancreatitis

[Biochemical Genetics] Investigators explored the role of long-noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in acute pancreatitis that was induced by caerulein in rat pancreatic acinar cells AR42J.

Novel Chloroquine Derivative Suppresses Melanoma Cell Growth by DNA Damage through Increasing ROS Levels

[Journal of Cellular and Molecular Medicine] Scientists found a novel chloroquine derivative, lj-2-66, that increased the level of reactive oxygen species (ROS) in melanoma cells and induced DNA damage, thus leading to G2/M arrest and apoptosis.

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