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flow cytometry

GAB1 Alleviates Septic Lung Injury by Inhibiting the TLR4/ NF-κB Pathway

[Clinical and Experimental Pharmacology and Physiology] Investigators investigated the involvement of GRB2-associated binding protein 1 (GAB1) in septic lung injury. Lipopolysaccharide induced mouse model and A549 cell model were used to similar the septic lung injury.

DNA Methylation-Mediated Low Expression of CFTR Stimulates the Progression of Lung Adenocarcinoma

[Biochemical Genetics] There is an urgent need to probe the molecular mechanism of lung adenocarcinoma (LUAD) progression, so as to disclose prognostic and diagnostic markers for patients with LUAD. qRT-PCR revealed that CFTR was lowly expressed in LUAD cells.

Puerarin Inhibits the PERK-eIF2α-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic Beta-Cells

[American Journal of Chinese Medicine] Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.

Pancreatic Cancer Cell-Derived MicroRNA-155-5p-Containing Extracellular Vesicles Promote Immune Evasion by Triggering EHF-Dependent Activation of Akt/NF-κB Signaling Pathway

[International Immunopharmacology] Ectopic expression and knockdown experiments were conducted in pancreatic cancer (PC) cells, PC cells-derived EVs, or mouse xenograft model of PC.

Combinational Blockade of MET and PD-L1 Improves Pancreatic Cancer Immunotherapeutic Efficacy

[Journal of Experimental & Clinical Cancer Research] Kaplan–Meier plotter was used to analyze the prognostic significance of each of the all-known receptor tyrosine kinases to date in immune “hot” and “cold” pancreatic cancers.

Feline Adipose-Derived Mesenchymal Stem Cells Induce Effector Phenotype and Enhance Cytolytic Function of CD8+ T Cells

[Stem Cell Research & Therapy] Modified mixed leukocyte reaction was performed between feline adipose-derived MSCs and PBMCs. Changes of cell cycle stages, phenotype and cellular senescence were determined through flow cytometry and gene expression analysis.

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