In Vitro Function and In Situ Localization of Multidrug Resistance-Associated Protein (MRP)1 (ABCC1) Suggest a Protective Role against Methyl Mercury-Induced Oxidative Stress in the Human Placenta

The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells’ glutathione status in equilibrium.
[Archives of Toxicology]
Granitzer, S., Ellinger, I., Khan, R., Gelles, K., Widhalm, R., Hengstschläger, M., Zeisler, H., Desoye, G., Tupova, L., Ceckova, M., Salzer, H., & Gundacker, C. (2020). In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology. https://doi.org/10.1007/s00204-020-02900-5 Cite
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Biochanin a Induces a Brown-Fat Phenotype via Improvement of Mitochondrial Biogenesis and Activation of AMPK Signaling in Murine C3H10T1/2 Mesenchymal Stem Cells

Scientists investigated the effect of Biochanin A, an O‐methylated isoflavone on the brown‐fat phenotype formation and on the associated thermogenic program including mitochondrial biogenesis and lipolysis in C3H10T1/2 MSCs.
[Phytotherapy Research]
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Adenovirus Infection Promotes the Formation of Glioma Stem Cells from Glioblastoma Cells through the TLR9/NEAT1/STAT3 Pathway

Infection of patient-derived glioma cells with adenovirus (ADV) increased the formation of tumor spheres. ADV infection upregulated stem cell markers and in turn promoted the capacities of self-renewal and multi-lineage differentiation of the infected tumor spheres.
[Cell Communication and Signaling]
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USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea

Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
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