Investigators designed and performed this study to determine whether exosomes attenuate the lesion size of spinal cord injury by ameliorating neuronal injury induced by a secondary inflammatory storm and promoting neurite outgrowth.
[Stem Cell Research & Therapy]
6445212 X3DA8E2K items 1 apa default asc 1
Wang, Y., Lai, X., Wu, D., Liu, B., Wang, N., & Rong, L. (2021). Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats. Stem Cell Research & Therapy, 12(1), 117. https://doi.org/10.1186/s13287-021-02148-5 Cite
Treatment with clusterin remarkably upregulated microtubule-associated protein 1-light chain 3 (LC3)-II conversion in a dose and time-dependent manner with a significant increase in the autophagy-related 3 gene expression level, which is a mediator of LC3-II conversion.
[Endocrinology and Metabolism]
6445212 D9P6NHDX items 1 apa default asc 1
Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived mesenchymal stem cells with knocked down Numb gene were treated with Huang Qi Decoction.
6445218 E5SANARY items 1 apa default asc 1
Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis | Scientific Reports. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41598-020-74324-1 Cite
Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived MSCs with knocked down Numb gene were treated with Huang Qi Decoction (HQD). Simultaneously, Numb gene knockdown was also performed in the WB-F344 cell line and then treated with refined HQD .
6630899 JKVWVG8P items 1 apa default asc 1
The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells’ glutathione status in equilibrium.
[Archives of Toxicology]
6630899 MXZTT3IT items 1 apa default asc 1
Granitzer, S., Ellinger, I., Khan, R., Gelles, K., Widhalm, R., Hengstschläger, M., Zeisler, H., Desoye, G., Tupova, L., Ceckova, M., Salzer, H., & Gundacker, C. (2020). In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology. https://doi.org/10.1007/s00204-020-02900-5 Cite
Scientists investigated the effect of Biochanin A, an O‐methylated isoflavone on the brown‐fat phenotype formation and on the associated thermogenic program including mitochondrial biogenesis and lipolysis in C3H10T1/2 MSCs.
6445218 V4EGTJX9 items 1 apa default asc 1
Rahman, M. S., Imran, K. M., Hossain, M., Lee, T.-J., & Kim, Y.-S. (n.d.). Biochanin A induces a brown-fat phenotype via improvement of mitochondrial biogenesis and activation of AMPK signaling in murine C3H10T1/2 mesenchymal stem cells. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6845 Cite
Infection of patient-derived glioma cells with adenovirus (ADV) increased the formation of tumor spheres. ADV infection upregulated stem cell markers and in turn promoted the capacities of self-renewal and multi-lineage differentiation of the infected tumor spheres.
[Cell Communication and Signaling]
1254621 K4D79NGZ items 1 apa default asc 1
Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
1254621 GG5QP5A9 items 1 apa default asc 1