Tag Archives: gene knockdown

Umbilical Mesenchymal Stem Cell-Derived Exosomes Facilitate Spinal Cord Functional Recovery through the miR-199a-3p/145–5p-Mediated NGF/TrkA Signaling Pathway in Rats

Investigators designed and performed this study to determine whether exosomes attenuate the lesion size of spinal cord injury by ameliorating neuronal injury induced by a secondary inflammatory storm and promoting neurite outgrowth.
[Stem Cell Research & Therapy]
Wang, Y., Lai, X., Wu, D., Liu, B., Wang, N., & Rong, L. (2021). Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats. Stem Cell Research & Therapy, 12(1), 117. https://doi.org/10.1186/s13287-021-02148-5 Cite
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Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells

Treatment with clusterin remarkably upregulated microtubule-associated protein 1-light chain 3 (LC3)-II conversion in a dose and time-dependent manner with a significant increase in the autophagy-related 3 gene expression level, which is a mediator of LC3-II conversion.
[Endocrinology and Metabolism]
Hong, S.-W., Lee, J., Kim, M. J., Moon, S. J., Kwon, H., Park, S. E., Rhee, E.-J., & Lee, W.-Y. (2020). Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells. Journal of Korean Endocrine Society. https://doi.org/.0.. Cite
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Hepatic Stem Cell Numb Gene Is a Potential Target of Huang Qi Decoction Against Cholestatic Liver Fibrosis

Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived mesenchymal stem cells with knocked down Numb gene were treated with Huang Qi Decoction.
[Scientific Reports]
Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis | Scientific Reports. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41598-020-74324-1 Cite
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Hepatic Stem Cell Numb Gene Is a Potential Target of Huang Qi Decoction against Cholestatic Liver Fibrosis

Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived MSCs with knocked down Numb gene were treated with Huang Qi Decoction (HQD). Simultaneously, Numb gene knockdown was also performed in the WB-F344 cell line and then treated with refined HQD .
[Scientific Reports]
Xu, W., Xu, Y., Zhang, X., Xu, Y., Jian, X., Chen, J., Chen, G., Zhang, H., Liu, P., & Mu, Y. (2020). Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis. Scientific Reports, 10(1), 17486. https://doi.org/10.1038/s41598-020-74324-1 Cite
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In Vitro Function and In Situ Localization of Multidrug Resistance-Associated Protein (MRP)1 (ABCC1) Suggest a Protective Role against Methyl Mercury-Induced Oxidative Stress in the Human Placenta

The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells’ glutathione status in equilibrium.
[Archives of Toxicology]
Granitzer, S., Ellinger, I., Khan, R., Gelles, K., Widhalm, R., Hengstschläger, M., Zeisler, H., Desoye, G., Tupova, L., Ceckova, M., Salzer, H., & Gundacker, C. (2020). In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology. https://doi.org/10.1007/s00204-020-02900-5 Cite
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Biochanin a Induces a Brown-Fat Phenotype via Improvement of Mitochondrial Biogenesis and Activation of AMPK Signaling in Murine C3H10T1/2 Mesenchymal Stem Cells

Scientists investigated the effect of Biochanin A, an O‐methylated isoflavone on the brown‐fat phenotype formation and on the associated thermogenic program including mitochondrial biogenesis and lipolysis in C3H10T1/2 MSCs.
[Phytotherapy Research]
Rahman, M. S., Imran, K. M., Hossain, M., Lee, T.-J., & Kim, Y.-S. (n.d.). Biochanin A induces a brown-fat phenotype via improvement of mitochondrial biogenesis and activation of AMPK signaling in murine C3H10T1/2 mesenchymal stem cells. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6845 Cite
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Adenovirus Infection Promotes the Formation of Glioma Stem Cells from Glioblastoma Cells through the TLR9/NEAT1/STAT3 Pathway

Infection of patient-derived glioma cells with adenovirus (ADV) increased the formation of tumor spheres. ADV infection upregulated stem cell markers and in turn promoted the capacities of self-renewal and multi-lineage differentiation of the infected tumor spheres.
[Cell Communication and Signaling]
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USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea

Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids]
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