Caspase-3/NLRP3 Signaling in the Mesenchymal Stromal Niche Regulates Myeloid-Biased Hematopoiesis

Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.
[Stem Cell Research & Therapy]
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Identification of ASCL1 as a Determinant for Human iPSC-Derived Dopaminergic Neurons

Differentiation platforms were established to model neural induction from stem cells, and scientists characterized these differentiated cell types by 10x single cell RNA sequencing.
[Scientific Reports]
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Introducing Dorsoventral Patterning in Adult Regenerating Lizard Tails with Gene-Edited Embryonic Neural Stem Cells

Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.
[Nature Communications]
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Fine-Tuned Repression of Drp1 Driven Mitochondrial Fission Primes a ‘Stem/Progenitor-Like State’ to Support Neoplastic Transformation

Using a newly derived carcinogen transformed human cell model, researchers demonstrated that fine-tuned Drp1 repression primed a slow cycling ‘stem/progenitor-like state’, which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
[eLife]
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The Potential Utility of Hybrid Photo-Crosslinked Hydrogels with Non-immunogenic Component for Cartilage Repair

A set of formulations consisting of photo-polymerizable Gel; photo-polymerizable hyaluronic acid, and allogenic decellularized cartilage matrix, was synthesized and characterized.
[NPJ Regenerative Medicine]
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The Relationship between Melanin Production and Lipofuscin Formation in Tyrosinase Gene Knockout Melanocytes Using CRISPR/Cas9 System

Scientists investigated the relationship between melanin production and lipofuscin synthesis in normal mouse melanoma cell line B16F1 cells and Tyrosinase gene knockout cells.
[Life Sciences]
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The Smac Mimetic BV6 Cooperates with STING to Induce Necroptosis in Apoptosis-Resistant Pancreatic Carcinoma Cells

Scientists demonstrated that the prototypical Smac mimetic BV6 cooperated with the stimulator of interferon genes ligand 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate to trigger necroptosis in apoptosis-deficient pancreatic cancer cells
[Cell Death & Disease]
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Nrf2 for Cardiac Protection: Pharmacological Options against Oxidative Stress

Myocardial ischemia or reperfusion increases the generation of reactive oxygen species from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation.
[Trends in Pharmacological Sciences]
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Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells

Investigators generated a ubiquitin-specific protease 3 gene knockout using the CRISPR/Cas9 system and demonstrated that USP3 acts as a protein stabilizer of Oct4 by deubiquitinating Oct4.
[International Journal of Molecular Sciences]
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Metformin Regulates the Th17/Treg Balance by Glycolysis with TIGAR in Hepatic Ischemia-Reperfusion Injury

The I/R liver injury rat model and the primary hepatocyte hypoxia/reoxygenation injury model were established. The biochemical indexes, inflammatory factor indexes, Th17/Treg balance and energy metabolism were evaluated.
[Journal of Pharmacological Sciences]
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Ferritinophagy Is Involved in the Zinc Oxide Nanoparticles-Induced Ferroptosis of Vascular Endothelial Cells

Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy]
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