Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
Tian, J., Wang, V., Wang, N., Khadang, B., Boudreault, J., Bakdounes, K., Ali, S., & Lebrun, J.-J. (2021). Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. Breast Cancer Research, 23(1), 23. https://doi.org/10.1186/s13058-021-01401-2Cite