Identification of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition

Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
[Breast Cancer Research]
Tian, J., Wang, V., Wang, N., Khadang, B., Boudreault, J., Bakdounes, K., Ali, S., & Lebrun, J.-J. (2021). Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. Breast Cancer Research, 23(1), 23. https://doi.org/10.1186/s13058-021-01401-2 Cite
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Withaferin A Alleviates Fulminant Hepatitis by Targeting Macrophage and NLRP3

Researchers evaluated the hepatoprotective role and mechanism of Withaferin A in D-galactosamine/lipopolysaccharide-induced fulminant hepatitis.
[Cell Death & Disease]
Xia, Y., Wang, P., Yan, N., Gonzalez, F. J., & Yan, T. (2021). Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death & Disease, 12(2), 1–14. https://doi.org/10.1038/s41419-020-03243-w Cite
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The Delay in Cell Death Caused by the Induction of Autophagy by P2Et Extract Is Essential for the Generation of Immunogenic Signals in Melanoma Cells

Scientists determined the role of autophagy in apoptosis and the generation of immunogenic signals using murine wild-type B16-F10 melanoma cells and cells with beclin-1 gene knockout.
[Apoptosis]
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