Tag Archives: genetic screen

Astrocytes Close a Motor Circuit Critical Period

Scientists defined a critical period in a developing Drosophila motor circuit and identified astrocytes as essential for proper critical period termination.
[Nature]
Ackerman, S. D., Perez-Catalan, N. A., Freeman, M. R., & Doe, C. Q. (2021). Astrocytes close a motor circuit critical period. Nature, 1–7. https://doi.org/10.1038/s41586-021-03441-2 Cite
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USP19 Modulates Cancer Cell Migration and Invasion and Acts as a Novel Prognostic Marker in Patients with Early Breast Cancer

Researchers identified the deubiquitinase USP19 and demonstrated that its silencing reduces the migratory and invasive potential of highly invasive breast cancer cell lines.
[Oncogenesis]
Rossi, F. A., Enriqué Steinberg, J. H., Calvo Roitberg, E. H., Joshi, M. U., Pandey, A., Abba, M. C., Dufrusine, B., Buglioni, S., De Laurenzi, V., Sala, G., Lattanzio, R., Espinosa, J. M., & Rossi, M. (2021). USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer. Oncogenesis, 10(3), 1–15. https://doi.org/10.1038/s41389-021-00318-x Cite
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Epidermal Progenitors Suppress GRHL3-Mediated Differentiation through Intronic Polyadenylation Promoted by CPSF-HNRNPA3 Collaboration

Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications]
Chen, X., Lloyd, S. M., Kweon, J., Gamalong, G. M., & Bao, X. (2021). Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications, 12(1), 448. https://doi.org/10.1038/s41467-020-20674-3 Cite
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Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer Cellular Migration and Invasion

Investigators performed a direct, unbiased chemical genetic screen to identify pro-viral integration site for Moloney murine leukemia virus-1 (PIM1) substrates in prostate cancer cells.
[Communications Biology]
Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6 Cite
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Branched-Chain Amino Acid Aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
[Cell Death & Differentiation]
Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., Gong, A., Wang, D., Cheng, F., & Zhu, H. (2020). Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00644-4 Cite
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The Rho-GEF PIX-1 Directs Assembly or Stability of Lateral Attachment Structures between Muscle Cells

Researchers showed that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, they found that pix-1 was required for the assembly of integrin adhesion complexes at borders between muscle cells, and was required for locomotion of the animal.
[Nature Communications]
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