Tag Archives: genetic screen

Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer Cellular Migration and Invasion

Investigators performed a direct, unbiased chemical genetic screen to identify pro-viral integration site for Moloney murine leukemia virus-1 (PIM1) substrates in prostate cancer cells.
[Communications Biology]
Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6 Cite
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Branched-Chain Amino Acid Aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
[Cell Death & Differentiation]
Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., Gong, A., Wang, D., Cheng, F., & Zhu, H. (2020). Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00644-4 Cite
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The Rho-GEF PIX-1 Directs Assembly or Stability of Lateral Attachment Structures between Muscle Cells

Researchers showed that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, they found that pix-1 was required for the assembly of integrin adhesion complexes at borders between muscle cells, and was required for locomotion of the animal.
[Nature Communications]
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