Ledet, R. J., Ruff, S. E., Wang, Y., Nayak, S., Schneider, J. A., Ueberheide, B., Logan, S. K., & Garabedian, M. J. (2021). Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Communications Biology, 4(1), 1–12. https://doi.org/10.1038/s42003-020-01528-6Cite
By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
Researchers showed that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, they found that pix-1 was required for the assembly of integrin adhesion complexes at borders between muscle cells, and was required for locomotion of the animal.