glioblastoma cells

[Biophysical Journal] Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.

[Developmental Cell] F3-antibody-sorted glioblastoma cells exhibited stem cell gene expression, enhanced self-renewal in culture, drove tumor initiation and serial transplantation, and reconstituted tumor heterogeneity.

[Developmental Cell] A derived quiescent cancer-stem-cell-specific gene expression signature was enriched in pre-formed patient glioblastoma xenograft single-cell clusters that lacked proliferative gene expression.

[Science Advances] After bilateral brain injections, nanotubes showed preferential retention by tumors compared to normal brain and were taken up by glioblastoma cells through scavenger receptor binding and macropinocytosis.

[Experimental Cell Research] Researchers explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.

[Advanced Materials] Researchers conducted transmission electron microscopy experiments of an intracranial glioblastoma model and showed that ligand-modified nanoparticles traversed the blood–brain barrier, endocytosed into the lysosomes of glioblastoma cells, and underwent endo-lysosomal escape upon photochemical ionization.