Glioblastoma Stem Cells Reprogram Chromatin In Vivo to Generate Selective Therapeutic Dependencies on DPY30 and Phosphodiesterases

Scientists identified DPY30, a regulator of histone H3 lysine 4 trimethylation, as a driver of glioblastoma growth in vivo but not in vitro.
[Science Translational Medicine]
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Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

To investigate recurrently dysregulated genes in glioblastoma, scientists interrogated allele-specific expression, the difference in expression between two alleles of a gene, in glioblastoma stem cells derived from 43 patients.
[Cancer Research]
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Novel Cancer Stem Cell Marker MVP Enhances Temozolomide-Resistance in Glioblastoma

Researchers found that sensitivity toTemozolomide (TMZ) was suppressed by significantly increasing the major vault protein (MVP) expression in glioblastoma multiforme cells with TMZ resistance.
[Translational Oncology]
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Competitive Binding of E3 Ligases TRIM26 and WWP2 Controls SOX2 in Glioblastoma

Investigators identified E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for glioblastoma stem cells identity and maintenance.
[Nature Communications]
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Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Scientists review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.
[Journal of Histochemistry & Cytochemistry]
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Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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Regulation of Gliomagenesis and Stemness through Acid Sensor ASIC1a

As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.
[International Journal of Oncology]
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Viral Targeting of Glioblastoma Stem Cells with Patient-Specific Genetic and Post-Translational p53 Deregulations

The authors dissected the genetic and functional heterogeneity of human glioblastoma stem cells within patients by their innate responses to non-pathogenic mouse parvoviruses that were tightly restrained by cellular physiology.
[Cell Reports]
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Targeting PUS7 Suppresses tRNA Pseudouridylation and Glioblastoma Tumorigenesis

Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.
[Nature Cancer]
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GRP78 Determines Glioblastoma Sensitivity to UBA1 Inhibition-Induced UPR Signaling and Cell Death

Scientists evaluated the functional activity and mechanism of TAK-243 in preclinical models of glioblastoma multiforme.
[Cell Death & Disease]
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