Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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Regulation of Gliomagenesis and Stemness through Acid Sensor ASIC1a

As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.
[International Journal of Oncology]
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Viral Targeting of Glioblastoma Stem Cells with Patient-Specific Genetic and Post-Translational p53 Deregulations

The authors dissected the genetic and functional heterogeneity of human glioblastoma stem cells within patients by their innate responses to non-pathogenic mouse parvoviruses that were tightly restrained by cellular physiology.
[Cell Reports]
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Targeting PUS7 Suppresses tRNA Pseudouridylation and Glioblastoma Tumorigenesis

Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.
[Nature Cancer]
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GRP78 Determines Glioblastoma Sensitivity to UBA1 Inhibition-Induced UPR Signaling and Cell Death

Scientists evaluated the functional activity and mechanism of TAK-243 in preclinical models of glioblastoma multiforme.
[Cell Death & Disease]
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Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
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Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
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Inhibition of Mitochondrial Translation Suppresses Glioblastoma Stem Cell Growth

Researchers explored the therapeutic potential of targeting mitochondrial translation and report the results of high-content screening with putative blockers of mitochondrial ribosomes.
[Cell Reports]
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Brd4-Bound Enhancers Drive Cell-Intrinsic Sex Differences in Glioblastoma

Researchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America]
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The Adaptive Transition of Glioblastoma Stem Cells and Its Implications on Treatments

Scientists summarize the basic characteristics, adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy.
[Signal Transduction and Targeted Therapy]
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PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells

The authors report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells, a subpopulation in glioblastoma critical for malignancy.
[Molecular Cell]
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