glioblastoma stem-like cells

[Photodiagnosis and Photodynamic Therapy] Scientists present a brief review exclusively commenting on the therapeutic approaches to eliminate glioblastoma stem cells and on the research publications about this topic of glioblastoma stem cells in relation to photodynamic therapy.

[Journal of Experimental & Clinical Cancer Research] Patient-derived glioma stem-like cells, glioblastoma (GBM) cell lines, intracranial GBM xenografts, and GBM sections were used to measure mRNA and protein expression and determine the related molecular mechanisms by qRT-PCR, immunoblot, immunoprecipitation, immunofluorescence, OCR, ECAR, live-cell imaging, and immunohistochemistry.

[Scientific Reports] The authors demonstrated that FOSL1 directly regulated four transcription factors bond to their promoter regions, was involved in the deregulation of several stemness markers, and reduced the cells’ ability to generate aggregates increasing the extracellular matrix component FN1.

[ACS Applied Materials & Interfaces] Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitate the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.

[Pharmacological Reports] Treatment with Tideglusib alone and in combination with radiation significantly decreased the colony formation of U-251 MG cells and the sphere formation of both cell lines, by targeting and reducing their glioblastoma cancer stem-like cells population.

[Cell Death & Disease] The authors performed in vitro and in vivo experiments, six human IDH1/2 wild-type glioblastoma stem-like cells were established and studied to determine a potential interaction of YKL-40 and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.