glioblastoma

[Cancer Research] To investigate recurrently dysregulated genes in glioblastoma, scientists interrogated allele-specific expression, the difference in expression between two alleles of a gene, in glioblastoma stem cells derived from 43 patients.

[Science Translational Medicine] Scientists found that lysine-specific histone demethylase 1 (LSD1) inhibition hampered the induction of the activating transcription factor 4, the master regulator of the integrated stress response.

[Cancer Science] Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.

[Science Advances] After bilateral brain injections, nanotubes showed preferential retention by tumors compared to normal brain and were taken up by glioblastoma cells through scavenger receptor binding and macropinocytosis.

[Scientific Reports] LncRNAs play critical roles in the tumorigenesis of glioblastoma (GBM) through regulation of various cancer-related genes and signaling pathways. Researchers focused on the essential role of EMT and identified 78 upregulated EMT-related genes in GBM through differential expression analysis.

[Scientific Reports] Scientists generated UM-002, a novel brain penetrant bromodomain and extraterminal domain (BET) inhibitor that reduced glioblastoma cell proliferation in vitro and in a human cerebral brain organoid model.