glioblastoma

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

[Nature] To systematically identify potential resistance pathways in an unbiased manner, scientists conducted a genome-wide CRISPR knockout screen in glioblastoma, a disease in which CAR T cells have had limited efficacy.

[Molecular Carcinogenesis] RNA TCF25 (circTCF25) was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reversed the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells.

[Translational Oncology] Scientists adapted a previously established brain tissue-model to fresh patient tumor cells with the goal of establishing 3D in vitro culture conditions for each tumor type.

[Cell Death & Disease] Researchers reported on the novel mechanism whereby overexpressed class I histone deacetylases increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide.

[Molecular Therapy] Researchers reported that FOSL1, a component of AP-1 transcription factor complexes, was a key player in regulating PMT. FOSL1 was predominantly expressed in the mesenchymal subtype, but not proneural subtype of glioblastoma stem cells.