glioblastoma

[Stem Cell Research & Therapy] Scientists explored the effect and mechanism of glioma-associated MSCs on resistance to temozolomide in glioma cells.

[Cancer Investigation] The authors summarize the temozolomide (TMZ)-resistance mechanisms and discuss several potential therapies from conservative opinion of glioma stem cell-targeted therapy orientation to current view of TMZ resistance-aimed efficacy.

[Journal of Clinical Investigation] Because the environmental and lifestyle factors that impact CSC populations are not clear, scientists sought to understand the consequences of diet on CSC enrichment.

[Nature Medicine] Researchers showed that engineering of a medium-length CAR spacer enhances the therapeutic efficacy of human erb-b2 receptor tyrosine kinase 2 (HER2)-specific CAR T cells in an orthotopic xenograft medulloblastoma model.

[ACS Applied Materials & Interfaces] Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitate the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.

[Nature Communications] Using comprehensive metabolomic profiling, scientists showed that methylthioadenosine (MTA) secreted by methylthioadenosine phosphorylaseMTAP-deleted cells in vitro resulted in high levels of extracellular MTA.