glioblastoma

[Scientific Reports] Utilizing dual-single guide RNAs (sgRNAs) and a homology-directed repair template with the CRISPR/Cas9 gene-editing system is a promising avenue for the treatment of glioblastoma multiforme.

[Journal of Clinical Investigation] Scientists interrogated the role of adenosine-to-Inosine RNA editing mediated by ADAR1 in glioblastoma stem cells and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells (NSCs).

[Developmental Cell] Researchers showed that reverse electron transfer through respiratory chain complex I was particularly active in brain cancer stem cells.

[Cancer Letters] Scientists reported that tumor suppressor candidate 2 (TUSC2) protein expression is reduced/lost in glioblastoma compared to normal brain due to protein destabilization.

[Biophysical Journal] Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.

[Signal Transduction and Targeted Therapy] Researchers showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.