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glioma stem cells

MCM8 Is Regulated by EGFR Signaling and Promotes the Growth of Glioma Stem Cells through Its Interaction with DNA-Replication-Initiating Factors

[Oncogene] The role of mini-chromosome maintenance 8 (MCM8) in glioblastomas has remained unclear. Scientists investigated the biological functions and mechanisms of MCM8 in glioma stem cells.

Prrx1 Promotes Stemness and Angiogenesis via Activating TGF-β/Smad Pathway and Upregulating Proangiogenic Factors in Glioma

[Cell Death & Disease] Aberrant expression of paired-related homeobox1 (Prrx1) has been functionally associated with cancer stem cells including glioma stem cells. Prrx1 was found to be markedly upregulated in glioma specimens and elevated Prrx1 expression was inversely correlated with prognosis of glioma patients.

Genetic Manipulation of Adhesion GPCR CD97/ADGRE5 Modulates Invasion in Patient-Derived Glioma Stem Cells

[Journal of Neuro-Oncology] Researchers examined CD97 function in primary patient-derived glioma stem cells obtained from five glioblastoma tumors, belonging to three major genetic subtypes.

FMR1/circCHAF1A/miR-211-5p/HOXC8 Feedback Loop Regulates Proliferation and Tumorigenesis via MDM2-Dependent p53 Signaling in GSCs

[Oncogene] The novel feedback loop among FMR1, circRNA-CHAF1A (circCHAF1A), miR-211-5p, and HOXC8 in glioma stem cells (GSCs) could facilitate the proliferation and tumorigenesis of glioma and GSCs

CD109-GP130 Interaction Drives Glioblastoma Stem Cell Plasticity and Chemoresistance through STAT3 Activity

[JCI Insight] Researchers reported CD109/STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of glioma stem cells and as a mediator of chemoresistance.

Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress

[Molecular Cancer Research] Researchers showed significant metabolic alterations occur in gliomas when perturbing the expression of asparagine synthetase, which is not merely restricted to amino acid homeostasis.

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