miR-204–Containing Exosomes Ameliorate GVHD-Associated Dry Eye Disease

Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.
[Science Advances]
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The Association of Graft-Versus-Leukemia Effect and Graft-Versus Host Disease in Haploidentical Transplantation with Post-Transplant Cyclophosphamide for AML

Investigators used a series of landmark analyses to investigate the association of of graft-versus-host disease in the setting of haploidentical SCT (haploSCT) with post-transplant cyclophosphamide in 805 acute myeloid leukemia patients following haploSCT.
[Bone Marrow Transplantation]
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Naive T Cell Depletion to Prevent Chronic Graft-Versus-Host Disease

138 patients with acute leukemia received Naive T cell-depleted peripheral blood stem-cell from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy.
[Journal of Clinical Oncology]
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Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia

The authors report on mechanism of action, safety, and efficacy data on combination strategies based on hypomethylating agents in the setting of post-allogeneic stem cell transplant relapse.
[Frontiers in Oncology]
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Use of CAR T Cell for Acute Lymphoblastic Leukemia (ALL) Treatment: A Review Study

Scientists discuss different generations, challenges, and clinical studies related to chimeric antigen receptor (CAR) T cells for ALL treatment.
[Cancer Gene Therapy]
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HLA 1–3 Antigen-Mismatched Related Peripheral Blood Stem Cells Transplantation Using Low-Dose Antithymocyte Globulin versus Unrelated Cord Blood Transplantation

Researchers evaluated 7861 patients with hematologic malignancies who received either a cord blood transplantr without anti-thymocyte globulin (ATG) or an HLA 1-3 antigen–mismatched related donor peripheral blood stem-cell transplantation using low-dose ATG.
[American Journal of Hematology]
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Post-Hematopoietic Stem Cell Transplantation Immune-Mediated Anemia: A Literature Review and Novel Therapeutics

Scientists summarize the literature on post-hematopoietic stem cell transplantation immune-mediated anemia with a focus on ABO and non-ABO blood group incompatibility, described the underlying mechanism of anemia, and outlined preventive and treatment approaches.
[Blood Advances]
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Cytokine Autoantibodies Are Stable throughout the Hematopoietic Stem Cell Transplantation Course and Are Associated with Distinct Biomarker and Blood Cell Profiles

Scientists found that cytokine-specific autoantibodies (c-aAb) levels were stable over the course of hematopoietic stem cell transplantation, including at high titres, with few individuals seeming to acquire high-titre levels of c-aAbs.
[Scientific Reports]
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Impact of Donor Types on Reduced-Intensity Conditioning Allogeneic Stem Cell Transplant for Mature Lymphoid Malignancies

Scientists retrospectively compared the outcomes of reduced-intensity conditioning transplantation from matched related donors matched unrelated donors, and umbilical cord blood for mature lymphoid malignancies.
[Bone Marrow Transplantation]
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Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

Scientists reported that the risk of donor cell leukemia in allogeneic hematopoietic cell transplantation was driven by somatic myelodysplastic syndrome–associated mutations or germline predisposition in donors.
[Journal of Clinical Oncology]
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Development of Allogeneic HSC-Engineered iNKT Cells for Off-the-Shelf Cancer Immunotherapy

By combining hematopoietic stem cell (HSC) gene engineering and in vitro differentiation, scientists generated human allogeneic HSC-engineered invariant natural killer T cells at high yield and purity.
[Cell Reports Medicine]
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