Scientists combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]
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Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease | Science Translational Medicine. (n.d.). Retrieved January 22, 2021, from https://stm.sciencemag.org/content/13/576/eabc0227 Cite
Researchers retrospectively analyzed the impact of Busulfan–Cyclophosphamide, Busulfan–Cyclophosphamide–Melphalan and Clofarabine–Fludarabine–Busulfan in pediatric AML-patients, with similar upfront leukemia treatment, receiving an hematopoietic cell transplant between 2010 and 2015.
[Bone Marrow Transplantation]
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Versluys, A. B., Boelens, J. J., Pronk, C., Lankester, A., Bordon, V., Buchner, J., Ifversen, M., Jackmann, N., Sundin, M., Vettenranta, K., Abrahamson, J., & Mellgren, K. (2021). Hematopoietic cell transplant in pediatric acute myeloid leukemia after similar upfront therapy; a comparison of conditioning regimens. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-01201-w Cite
Scientists investigated the correlation between the gene polymorphisms within the HLA region and the adverse reactions of post-hematopoietic stem cell transplantation in patients with acute leukemia, where 72 patients were diagnosed with acute lymphocytic leukemia and 104 were acute myeloid leukemia.
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Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
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Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
Scientists provide an overview of clinical results obtained through the use of haploidentical transplantation in severe aplastic anemia, mainly focusing on current advances and future challenges.
[Bone Marrow Transplantation]
By analogy, SARS-CoV-2 is a vector that initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences.
Disease status before hematopoietic stem cell transplantation was bone marrow failure in 30 patients and myelodysplastic syndrome in four.
[Bone Marrow Transplantation]
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Murillo-Sanjuán, L., González-Vicent, M., Argilés Aparicio, B., Badell Serra, I., Rodríguez Villa, A., Uria Oficialdegui, M. L., López-Duarte, M., Beléndez-Bieler, C., Sastre Urgelles, A., Sevilla Navarro, J., & Diaz-de-Heredia, C. (2020). Survival and toxicity outcomes of hematopoietic stem cell transplantation for pediatric patients with Fanconi anemia: a unified multicentric national study from the Spanish Working Group for Bone Marrow Transplantation in Children. Bone Marrow Transplantation, 1–4. https://doi.org/10.1038/s41409-020-01172-y Cite
To assess the relevance of autophagy to T cell allo-immunity, the authors generated T cell specific ATG5 knock-out mice. Deficiency of ATG5 dependent autophagy reduced T cell proliferation, increased apoptosis following in vitro and in vivo allo-stimulation.
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Oravecz-Wilson, K., Rossi, C., Zajac, C., Sun, Y., Li, L., Decoville, T., Fujiwara, H., Kim, S., Peltier, D., & Reddy, P. (2020). ATG5-dependent autophagy uncouples T cell proliferative and effector functions and separates graft-versus-host disease from graft-versus-leukemia. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1346 Cite
Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
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Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
The authors define the role of administrating fecal microbiota transplantation in the setting of allogeneic hematopoietic stem cell transplantation.
Scientists conducted two clinical trials to verify the safety and efficacy of GC027, an “off-the-shelf” allogeneic CAR-T product targeting T cell antigen CD7. Here we report two patients as case reports with relapsed/refractory T-ALL who were treated with GC027.
[Clinical Cancer Research]
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Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., Wu, K., Liu, J., Yang, C., Li, Z., Wang, D., Shen, L., Ye, X., He, J., Han, C., Wang, Y., Zhang, D., Dong, Y., Fang, L., … Wang, S. (2020). Eradication of T-ALL cells by CD7 targeted universal CAR-T cells and initial test of ruxolitinib-based CRS management. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1271 Cite