Prognostic Impacts of Peripheral Blood Erythroblasts after Single-Unit Cord Blood Transplantation

Researchers investigated the impact of erythroblasts on transplant outcomes on 225 adult patients who underwent single-unit cord blood transplantation at our single institute.
[International Journal of Laboratory Hematology]
Kaito, Y., Konuma, T., Monna-Oiwa, M., Kato, S., Isobe, M., Okabe, M., Imai, Y., Takahashi, S., & Tojo, A. (n.d.). Prognostic impacts of peripheral blood erythroblasts after single-unit cord blood transplantation. International Journal of Laboratory Hematology, n/a(n/a). https://doi.org/10.1111/ijlh.13622 Cite
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Incidence and Risk Factors of Late-Onset Hemorrhagic Cystitis after Single Umbilical Cord Blood Transplantation with Myeloablative Conditioning Regimen

Scientists explored the incidence and risk factors of late-onset hemorrhagic cystitis in patients undergoing single umbilical cord blood transplantation for hematological malignancies.
[International Journal of Hematology]
Jiang, H., Geng, L., Wan, X., Song, K., Tong, J., Zhu, X., Tang, B., Yao, W., Zhang, X., Sun, G., Zhang, L., Sun, Z., & Liu, H. (2021). Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen. International Journal of Hematology. https://doi.org/10.1007/s12185-021-03168-w Cite
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Cryopreservation of Unrelated Donor Hematopoietic Stem Cells: The Right Answer for Transplantations during the COVID-19 Pandemic?

Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.
[Bone Marrow Transplantation]
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Insights from Integrating Clinical and Preclinical Studies Advance Understanding of Graft-versus-Host Disease

Scientists review selected recent advances both in preclinical experimental transplantation and translational human studies, including new insights into human immunology, the microbiome, and regenerative medicine.
[Journal of Clinical Investigation]
Socié, G., Kean, L. S., Zeiser, R., & Blazar, B. R. (2021). Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI149296 Cite
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NFAT Signaling in Human Mesenchymal Stromal Cells Affects Extracellular Matrix Remodeling and Anti-Fungal Immune Responses

RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.
[iScience]
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COVID-19 and Stem Cell Transplantation; Results from an EBMT and GETH Multicenter Prospective Survey

The authors reported on 382 COVID-19 patients having undergone allogeneic or autologous hematopoietic cell transplantation reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH).
[Leukemia]
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Allogeneic Stem Cell Transplantation for AML Patients with RUNX1 Mutation in First Complete Remission: A Study on Behalf of the Acute Leukemia Working Party of the EBMT

Researchers performed a retrospective, registry-based analysis to elucidate the prognostic value of runt-related transcription factor 1 (RUNX1) mutation after allogeneic stem cell transplantation for AML patients.
[Bone Marrow Transplantation]
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Severe Infections and Infection-Related Mortality in a Large Series of Haploidentical Hematopoietic Stem Cell Transplantation with Post-transplant Cyclophosphamide

Investigators reported 236 adult patients who received haploidentical HSC transplantation with post-transplant cyclophosphamide.
[Bone Marrow Transplantation]
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Prolonged Suppression of Butyrate Producing Bacteria Is Associated with Acute Gastrointestinal Graft-versus-Host Disease and Transplant Related Mortality after Allogeneic Stem Cell Transplantation

Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.
[Clinical infectious Diseases]
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Low-Dose Antithymocyte Globulin plus Low-Dose Posttransplant Cyclophosphamide Combined with Cyclosporine and Mycophenolate Mofetil for Prevention of Graft-versus-Host Disease after HLA-Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation

To improve the efficiency of graft-versus-host disease (GvHD) prophylaxis in matched unrelated donor peripheral blood stem cell transplantation, 51 patients with hematological malignancies received a novel regimen for GvHD prophylaxis composed of low dose antithymocyte globulin.
[Bone Marrow Transplantation]
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Development of CAR T-cell Lymphoma in Two of Ten Patients Effectively Treated with piggyBac Modified CD19 CAR T-cells

The authors demonstrated the feasibility of generating CD19-specific chimeric antigen receptor (CAR19) T-cells from HLA-matched donors of sibling allogeneic hematopoietic stem cell transplant patients via a simple and inexpensive method using the piggyBac transposon.
[Blood]
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