Spatiotemporal Single-Cell Profiling Reveals That Invasive and Tissue-Resident Memory Donor CD8+ T Cells Drive Gastrointestinal Acute Graft-Versus-Host Disease

Scientists combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease | Science Translational Medicine. (n.d.). Retrieved January 22, 2021, from https://stm.sciencemag.org/content/13/576/eabc0227 Cite
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Hematopoietic Cell Transplant in Pediatric Acute Myeloid Leukemia after Similar Upfront Therapy; A Comparison of Conditioning Regimens

Researchers retrospectively analyzed the impact of Busulfan–Cyclophosphamide, Busulfan–Cyclophosphamide–Melphalan and Clofarabine–Fludarabine–Busulfan in pediatric AML-patients, with similar upfront leukemia treatment, receiving an hematopoietic cell transplant between 2010 and 2015.
[Bone Marrow Transplantation]
Versluys, A. B., Boelens, J. J., Pronk, C., Lankester, A., Bordon, V., Buchner, J., Ifversen, M., Jackmann, N., Sundin, M., Vettenranta, K., Abrahamson, J., & Mellgren, K. (2021). Hematopoietic cell transplant in pediatric acute myeloid leukemia after similar upfront therapy; a comparison of conditioning regimens. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-01201-w Cite
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The Adverse Events of Hematopoietic Stem Cell Transplantation Are Associated with Gene Polymorphism within Human Leukocyte Antigen Region

Scientists investigated the correlation between the gene polymorphisms within the HLA region and the adverse reactions of post-hematopoietic stem cell transplantation in patients with acute leukemia, where 72 patients were diagnosed with acute lymphocytic leukemia and 104 were acute myeloid leukemia.
[Scientific Reports]
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Feasibility of Reduced-Dose Posttransplant Cyclophosphamide and Cotransplantation of Peripheral Blood Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells for SAA

Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
[Scientific Reports]
Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
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Haploidentical Stem Cell Transplantation for Aplastic Anemia: The Current Advances and Future Challenges

Scientists provide an overview of clinical results obtained through the use of haploidentical transplantation in severe aplastic anemia, mainly focusing on current advances and future challenges.
[Bone Marrow Transplantation]
Xu, Z.-L., & Huang, X.-J. (2020). Haploidentical stem cell transplantation for aplastic anemia: the current advances and future challenges. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-020-01169-7 Cite
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COVID-19 and Graft-Versus-Host Disease: A Tale of Two Diseases

By analogy, SARS-CoV-2 is a vector that initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences.
[Laboratory Investigation]
Murphy, G. F. (2020). COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters). Laboratory Investigation, 1–6. https://doi.org/10.1038/s41374-020-00520-2 Cite
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Survival and Toxicity Outcomes of Hematopoietic Stem Cell Transplantation for Pediatric Patients with Fanconi Anemia: A Unified Multicentric National Study from the Spanish Working Group for Bone Marrow Transplantation in Children

Disease status before hematopoietic stem cell transplantation was bone marrow failure in 30 patients and myelodysplastic syndrome in four.
[Bone Marrow Transplantation]
Murillo-Sanjuán, L., González-Vicent, M., Argilés Aparicio, B., Badell Serra, I., Rodríguez Villa, A., Uria Oficialdegui, M. L., López-Duarte, M., Beléndez-Bieler, C., Sastre Urgelles, A., Sevilla Navarro, J., & Diaz-de-Heredia, C. (2020). Survival and toxicity outcomes of hematopoietic stem cell transplantation for pediatric patients with Fanconi anemia: a unified multicentric national study from the Spanish Working Group for Bone Marrow Transplantation in Children. Bone Marrow Transplantation, 1–4. https://doi.org/10.1038/s41409-020-01172-y Cite
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ATG5-Dependent Autophagy Uncouples T Cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia

To assess the relevance of autophagy to T cell allo-immunity, the authors generated T cell specific ATG5 knock-out mice. Deficiency of ATG5 dependent autophagy reduced T cell proliferation, increased apoptosis following in vitro and in vivo allo-stimulation.
[Cancer Research]
Oravecz-Wilson, K., Rossi, C., Zajac, C., Sun, Y., Li, L., Decoville, T., Fujiwara, H., Kim, S., Peltier, D., & Reddy, P. (2020). ATG5-dependent autophagy uncouples T cell proliferative and effector functions and separates graft-versus-host disease from graft-versus-leukemia. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1346 Cite
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Logistics of an Advanced Therapy Medicinal Product during COVID-19 Pandemic in Italy: Successful Delivery of Mesenchymal Stromal Cells in Dry Ice

Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
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The Clinical Role of the Gut Microbiome and Fecal Microbiota Transplantation in Allogeneic Stem Cell Transplantation

The authors define the role of administrating fecal microbiota transplantation in the setting of allogeneic hematopoietic stem cell transplantation.
[Haematologica]
Henig, I., Yehudai-Ofir, D., & Zuckerman, T. (2020). The clinical role of the gut microbiome and fecal microbiota transplantation in allogeneic stem cell transplantation. Haematologica. https://doi.org/10.3324/haematol.2020.247395 Cite
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Eradication of T-ALL Cells by CD7 Targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-Based CRS Management

Scientists conducted two clinical trials to verify the safety and efficacy of GC027, an “off-the-shelf” allogeneic CAR-T product targeting T cell antigen CD7. Here we report two patients as case reports with relapsed/refractory T-ALL who were treated with GC027.
[Clinical Cancer Research]
Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., Wu, K., Liu, J., Yang, C., Li, Z., Wang, D., Shen, L., Ye, X., He, J., Han, C., Wang, Y., Zhang, D., Dong, Y., Fang, L., … Wang, S. (2020). Eradication of T-ALL cells by CD7 targeted universal CAR-T cells and initial test of ruxolitinib-based CRS management. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1271 Cite
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