graft-versus-host disease

[Blood] The authors demonstrated the feasibility of generating CD19-specific chimeric antigen receptor (CAR19) T-cells from HLA-matched donors of sibling allogeneic hematopoietic stem cell transplant patients via a simple and inexpensive method using the piggyBac transposon.

[Archivum Immunologiae Et therapiae Experimentalis] The authors summarize recent advances in knowledge about osteopontin function in the kidney, heart, liver, lung, and hematopoietic stem cell transplantation.

[New England Journal of Medicine] Scientists treated 50 patients with Severe combined immunodeficiency due to adenosine deaminase (ADA) with an investigational gene therapy composed of autologous CD34+ hematopoietic stem and progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA.

[Bone Marrow Transplantation] Initial experience with Temcell, a cryopreserved, human bone marrow-derived MSC product, in a real-world setting from a cellular therapy registry in Japan is presented.

[Bone Marrow Transplantation] Analysis of CD45RA-depleted haploidentical mixed lymphocytes culture revealed insufficient suppression of alloresponses in the CD4+ compartment and identified CD276 as a marker for alloreactive memory Th1 T cells.

[Bone Marrow Transplantation] 12 patients with primary or secondary graft failure received T-cell replete bone marrow grafts from haploidentical donors and post-transplantation cyclophosphamide.