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graft-versus-host disease

CD3 Engagement as a New Strategy for Allogeneic “Off-the-Shelf” T Cell Therapy

[Molecular Therapy-Oncolytics] Bi-specific T cell engager (BiTE-T) cells down-regulated CD3ε/TCRαβ on bystander T cells by releasing BiTEs.

Early Vascular Toxicity after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation

[Bone Marrow Transplantation] The authors evaluated the prevalence of key vascular complications and graft-versus-host disease among 122 pediatric patients with an allogeneic hematopoietic stem cell transplantation between 2001 and 2013.

Individualized Dosing of Anti-Thymocyte Globulin in Pediatric Unrelated Allogeneic Hematopoietic Stem-Cell Transplantation (PARACHUTE): A Single-Arm, Phase II Clinical Trial

[Lancet Haematology] Scientists reported the results of a prospective, single-arm, Phase II clinical trial done at the University Medical Center Utrecht and the Princess Máxima Center for Pediatric Oncology to investigate individualized dosing of anti-thymocyte globulin for unrelated allogeneic HSC transplantation in pediatric patients.

NorthSea Therapeutics Initiates Phase 1 Trial of SEFA-6179, Targeting the Orphan Indication Intestinal Failure-Associated Liver Disease

[NorthSea Therapeutics B.V.] NorthSea Therapeutics B.V. announced it has initiated a Phase I study with SEFA-6179 in adult subjects, targeting the initial orphan indication of the treatment of intestinal failure associated liver disease.

Human Invariant Natural Killer T Cells Promote Tolerance by Preferential Apoptosis Induction of Conventional Dendritic Cells

[Haematologica] Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.

Accelerated Embryonic Stem Cell Screening with a Highly Efficient Genotyping Pipeline

[Molecular Biology Reports] Scientists optimized and functionally linked magnetic activated cell sorting technology as well as multiplex droplet digital PCR to their ESC screening process to achieve a greater than 60% assurance that ESC clones were correctly targeted.

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