graft-versus-host disease

[Science Immunology] Researchers identified and characterize skin-resident T cells in humans defined by their long-term in situ lodgment.

[Therapeutic Advances in Hematology] Scientists identified the efficacy and safety of MSCs for multidrug-resistant-graft-versus-host disease after haploidentical donor hematopoietic stem cell transplantation.

[Science Advances] Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.

[Bone Marrow Transplantation] Investigators used a series of landmark analyses to investigate the association of of graft-versus-host disease in the setting of haploidentical SCT (haploSCT) with post-transplant cyclophosphamide in 805 acute myeloid leukemia patients following haploSCT.

[Frontiers in Oncology] The authors report on mechanism of action, safety, and efficacy data on combination strategies based on hypomethylating agents in the setting of post-allogeneic stem cell transplant relapse.

[Cancer Gene Therapy] Scientists discuss different generations, challenges, and clinical studies related to chimeric antigen receptor (CAR) T cells for ALL treatment.