graft-versus-host disease

[Journal of Clinical Oncology] 138 patients with acute leukemia received Naive T cell-depleted peripheral blood stem-cell from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy.

[American Journal of Hematology] Researchers evaluated 7861 patients with hematologic malignancies who received either a cord blood transplantr without anti-thymocyte globulin (ATG) or an HLA 1-3 antigen–mismatched related donor peripheral blood stem-cell transplantation using low-dose ATG.

[Blood Advances] Scientists summarize the literature on post-hematopoietic stem cell transplantation immune-mediated anemia with a focus on ABO and non-ABO blood group incompatibility, described the underlying mechanism of anemia, and outlined preventive and treatment approaches.

[Scientific Reports] Scientists found that cytokine-specific autoantibodies (c-aAb) levels were stable over the course of hematopoietic stem cell transplantation, including at high titres, with few individuals seeming to acquire high-titre levels of c-aAbs.

[Bone Marrow Transplantation] Scientists retrospectively compared the outcomes of reduced-intensity conditioning transplantation from matched related donors matched unrelated donors, and umbilical cord blood for mature lymphoid malignancies.

[Journal of Clinical Oncology] Scientists reported that the risk of donor cell leukemia in allogeneic hematopoietic cell transplantation was driven by somatic myelodysplastic syndrome–associated mutations or germline predisposition in donors.