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granulocytes

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

[American Journal of Respiratory and Critical Care Medicine] Human and mouse model bronchoalveolar lavage fluid samples were analyzed for the presence and activity of cathepsin S and its endogenous inhibitors.

LRG1: An Emerging Player in Disease Pathogenesis

[Journal of Biomedical Science] Emphasis is given to the role that leucine-rich α-2 glycoprotein 1 (LRG1) plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment.

M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

[Scientific Reports] The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.

Matrix Metalloproteinases (MMP) 3 and 9 as Biomarkers of Severity in COVID-19 Patients

[Scientific Reports] Investigators studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in 108 hospitalized patients with different World Health Organization severity stage and in 48 controls.

A MicroRNA Checkpoint for Ca2+ Signaling and Overload in Acute Pancreatitis

[Molecular Therapy] Scientists showed that microRNA-26a inhibited pancreatic acinar cell store-operated Ca2+ entry channel expression, Ca2+ overload, and acute pancreatitis.

VEGF Signaling Causes Stalls in Brain Capillaries and Reduces Cerebral Blood Flow in Alzheimer’s Mice

[Brain] Scientists reported that VEGF signaling at the luminal side of the brain microvasculature played an integral role in the capillary stalling phenomenon of the APP/PS1 mouse model.

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