MiR-367-3p Downregulates Rab23 Expression and Inhibits Hedgehog Signaling Resulting in the Inhibition of the Proliferation, Migration, and Invasion of Prostate Cancer Cells

Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.
[Oncology Reports]
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The Hedgehog Pathway Suppresses Neuropathogenesis in CD4 T Cell-Driven Inflammation

Researchers showed that the CNS-endogenous hedgehog pathway attenuated the pathogenicity of human and mouse effector CD4 T cells by regulating their production of inflammatory cytokines.
[Brain]
Benallegue, N., Kebir, H., Kapoor, R., Crockett, A., Li, C., Cheslow, L., Abdel-Hakeem, M. S., Gesualdi, J., Miller, M. C., Wherry, E. J., Church, M. E., Blanco, M. A., & Alvarez, J. I. (2021). The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. Brain, awab083. https://doi.org/10.1093/brain/awab083 Cite
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Upregulation of LINC01426 Promotes the Progression and Stemness in Lung Adenocarcinoma by Enhancing the Level of SHH Protein to Activate the Hedgehog Pathway

Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.
[Cell Death & Disease]
Liu, X., Yin, Z., Xu, L., Liu, H., Jiang, L., Liu, S., & Sun, X. (2021). Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway. Cell Death & Disease, 12(2), 1–13. https://doi.org/10.1038/s41419-021-03435-y Cite
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Smoothened-Activating Lipids Drive Resistance to CDK4/6 Inhibition in Hedgehog-Associated Medulloblastoma Cells and Preclinical Models

Scientists identified resistance mechanisms to CDK6 inhibition in Hedgehog (HH)-associated medulloblastoma by performing orthogonal CRISPR and CRISPR interference screens in medulloblastoma cells treated with a CDK4/6 inhibitor, and RNA-sequencing of a mouse model of HH-associated medulloblastoma with genetic deletion of Cdk6.
[Journal of Clinical Investigation]
JCI - Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models. (n.d.). Retrieved January 22, 2021, from https://www.jci.org/articles/view/141171 Cite
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Mesenchymal Stem Cells Reverse EMT Process through Blocking the Activation of NF-κB and Hedgehog Pathways in LPS-Induced Acute Lung Injury

Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease]

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Berberine Inhibits Colorectal Tumor Growth by Suppressing SHH Secretion

Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.
[Acta Pharmacologica Sinica]
Berberine inhibits colorectal tumor growth by suppressing SHH secretion | Acta Pharmacologica Sinica. (n.d.). Retrieved September 21, 2020, from https://www.nature.com/articles/s41401-020-00514-2 Cite
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TET1 Downregulates Epithelial-Mesenchymal Transition and Chemoresistance in PDAC by Demethylating CHL1 to Inhibit the Hedgehog Signaling Pathway

In vitro and in vivo functional studies performed by silencing or overexpressing TET1 suggested that TET1 was able to suppress epithelial-mesenchymal transition and sensitize pancreatic ductal adenocarcinoma cells to 5FU and gemcitabine. RNA-seq, whole genome bisulfite sequencing and ChIP-seq were used to explore the TET1-associated pathway, and showed that TET1 promoted the transcription of CHL1 by binding and demethylating the CHL1 promoter, which consequently inhibits the Hedgehog pathway.
[Oncogene]
Li, H., Jiang, W., Liu, X.-N., Yuan, L.-Y., Li, T.-J., Li, S., Xu, S.-S., Zhang, W.-H., Gao, H.-L., Han, X., Wang, W.-Q., Wu, C.-T., Yu, X.-J., Xu, H.-X., & Liu, L. (2020). TET1 downregulates epithelial-mesenchymal transition and chemoresistance in PDAC by demethylating CHL1 to inhibit the Hedgehog signaling pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01407-8 Cite
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24‐Dehydrocholesterol Reductase Promotes the Growth of Breast Cancer Stem‐like Cells through the Hedgehog Pathway

DHCR24 knockdown reduced whereas DHCR24 overexpression enhanced breast cancer stem‐like cell populations such as mammosphere and aldehyde dehydrogenase positive cell numbers. In addition, DHCR24 overexpression increased the expression of the Hedgehog pathway regulated genes.
[Cancer Science]
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Itraconazole Inhibits the Hedgehog Signaling Pathway Thereby Inducing Autophagy-Mediated Apoptosis of Colon Cancer Cells

Researchers investigated whether itraconazole induced autophagy-mediated cell death of colon cancer cells through the Hedgehog signaling pathway.
[Cell Death & Disease]
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