hedgehog pathway

[Bone Research] The authors consider both in vitro and in vivo studies that examine the role of Hedgehog in repair and discuss some of the challenges inherent in their interpretation.

[Diabetes Research and Clinical Practice] Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.

[Cell Reports] Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.

[Communications Biology] The identity of a glycinergic synapse was maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptured glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.

[Stem Cell Research & Therapy] Scientists highlight the potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing.

[Toxicological Sciences] Cadmium-induced malignant transformation of human bronchial epithelia BEAS-2B cells was accomplished by a nine-month low dose Cd exposure. The Cd-exposed cells formed significantly more colonies in soft agar, displayed CSC-like properties and formed tumors in nude mice.