Investigators developed a one‐size‐fits‐all editing strategy for effective T‐cell correction, selection, and depletion and investigated the therapeutic potential of T‐cell and hematopoietic stem/progenitor cell therapies in the hyper‐IgM syndrome mouse model.
[EMBO Molecular Medicine]
Vavassori, V., Mercuri, E., Marcovecchio, G. E., Castiello, M. C., Schiroli, G., Albano, L., Margulies, C., Buquicchio, F., Fontana, E., Beretta, S., Merelli, I., Cappelleri, A., Rancoita, P. M., Lougaris, V., Plebani, A., Kanariou, M., Lankester, A., Ferrua, F., Scanziani, E., … Genovese, P. (2021). Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome. EMBO Molecular Medicine, n/a(n/a), e13545. https://doi.org/10.15252/emmm.202013545 Cite
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