Scientists tested the safety and efficacy of chimeric antigen receptor T cell therapy in refractory/relapsed acute myeloid leukemia .
[Clinical Cancer Research]
Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
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Thulin, M. H., Määttä, J., Linder, A., Sterbova, S., Ohlsson, C., Damber, J.-E., Widmark, A., & Persson, E. (n.d.). Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24125 Cite
To characterize glycosylphosphatidylinositol-anchored protein-deficient and HLA-class I allele-lacking hematopoietic stem progenitor cells in acquired aplastic anemia (AA), researchers studied the peripheral blood of 56 AA patients in remission.
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Yoroidaka, T., Hosokawa, K., Imi, T., Mizumaki, H., Katagiri, T., Ishiyama, K., Yamazaki, H., Azuma, F., Nanya, Y., Ogawa, S., & Nakao, S. (2021). Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia. Leukemia, 1–11. https://doi.org/10.1038/s41375-021-01202-8 Cite
Investigators highlight two areas in the field of HSC research, which just started to unlock the possibilities provided by novel biomaterials, in vitro blood production and studying the pathophysiology of the niche in vitro.
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Chatterjee, C., Schertl, P., Frommer, M., Ludwig-Husemann, A., Mohra, A., Dilger, N., Naolou, T., Meermeyer, S., Bergmann, T. C., Calleja, A. A., & Lee-Thedieck, C. (2021). Rebuilding the hematopoietic stem cell niche: recent developments and future prospects. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.03.061 Cite
Researchers conducted retrospective multicenter analysis of patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes who had hematological relapse after allogeneic hematopoietic stem cell transplantation and were treated with azacitidine for this indication.
[European Journal of Haematology]
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Drozd‐Sokołowska, J., Karakulska‐Prystupiuk, E., Biecek, P., Kobylińska, K., Piekarska, A., Dutka, M., Waszczuk‐Gajda, A., Mądry, K., Kopińska, A., Gołos, A., Góra‐Tybor, J., Szwedyk, P., Bołkun, Ł., Czyż, A., Giebel, S., Basak, G. W., & Dwilewicz‐Trojaczek, J. (n.d.). Azacitidine for relapse of acute myeloid leukemia or myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation, multicenter PALG analysis. European Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/ejh.13628 Cite
Researchers demonstrated that LaminA/C defined a distinct repressive nuclear compartment for X chromosome inactivation (XCI) in young HSCs, and its reduction in aged HSCs correlated with an impairment in the overall control of XCI.
[Stem Cell Reports]
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Investigators found increased nitric oxide during HSC regeneration with an accumulation of protein aggregation.
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Yi, W., Zhang, Y., Liu, B., Zhou, Y., Liao, D., Qiao, X., Gao, D., Xie, T., Yao, Q., Zhang, Y., Qiu, Y., Huang, G., Chen, Z., Chen, C., & Ju, Z. (2021). Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Reports, 34(13). https://doi.org/10.1016/j.celrep.2021.108922 Cite
Using single-cell RNA-sequencing, researchers deciphered a dynamic atlas covering 28,777 cells and nine major cell types of zebrafish caudal hematopoietic tissue.
[Proceedings of the National Academy of Sciences of the United States of America]
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Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.-D. J., & Liu, F. (2021). A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences, 118(14). https://doi.org/10.1073/pnas.2015748118 Cite
Investigators showed that in vivo flux experiments that came from different laboratories could all be reconciled into a single unifying model, even though they had previously been interpreted as being contradictory.
[Stem Cell Reports]
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Takahashi, M., Barile, M., Chapple, R. H., Tseng, Y., Nakada, D., Busch, K., Fanti, A.-K., Säwén, P., Bryder, D., Höfer, T., & Göttgens, B. (2021). Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.02.020 Cite
Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
Loss of Setd2 in hematopoietic cells ablated H3K36me3, and led to anemia with a significant decrease in erythroid cells in the peripheral blood at E18.5.
[Biochemical and Biophysical Research Communications]
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Li, Y., Tang, H., Chen, F., Chen, J., Wang, H., Chen, Z., Duan, Y., Wang, X., Li, L., & Ouyang, K. (2021). SETD2 is essential for terminal differentiation of erythroblasts during fetal erythropoiesis. Biochemical and Biophysical Research Communications, 552, 98–105. https://doi.org/10.1016/j.bbrc.2021.03.040 Cite