Tag Archives: hematopoietic stem cells

Tissue-Resident Macrophages Provide a Pro-tumorigenic Niche to Early NSCLC Cells

To explore the diversity of the macrophage compartment in human non-small cell lung carcinoma (NSCLC) lesions, researchers performed single-cell RNA sequencing of tumour-associated leukocytes.
[Nature]
Casanova-Acebes, M., Dalla, E., Leader, A. M., LeBerichel, J., Nikolic, J., Morales, B. M., Brown, M., Chang, C., Troncoso, L., Chen, S. T., Sastre-Perona, A., Park, M. D., Tabachnikova, A., Dhainaut, M., Hamon, P., Maier, B., Sawai, C. M., Agulló-Pascual, E., Schober, M., … Merad, M. (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature, 1–7. https://doi.org/10.1038/s41586-021-03651-8 Cite
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iNKT Cells Coordinate Immune Pathways to Enable Engraftment in Nonconditioned Hosts

Using a human umbilical cord blood xenotransplantation model, we show here that co-transplanted allogeneic CD4+ iNKT cells interact with monocytes and T cells in the graft to coordinate pro-hematopoietic and immunoregulatory pathways.
[Life Science Alliance]
Hess, N. J., Bharadwaj, N. S., Bobeck, E. A., McDougal, C. E., Ma, S., Sauer, J.-D., Hudson, A. W., & Gumperz, J. E. (2021). iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts. Life Science Alliance, 4(7). https://doi.org/10.26508/lsa.202000999 Cite
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Tissue-Resident Macrophages Provide a Pro-tumorigenic Niche to Early NSCLC Cells

Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.
[Nature]
Casanova-Acebes, M., Dalla, E., Leader, A. M., LeBerichel, J., Nikolic, J., Morales, B. M., Brown, M., Chang, C., Troncoso, L., Chen, S. T., Sastre-Perona, A., Park, M. D., Tabachnikova, A., Dhainaut, M., Hamon, P., Maier, B., Sawai, C. M., Agulló-Pascual, E., Schober, M., … Merad, M. (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature, 1–7. https://doi.org/10.1038/s41586-021-03651-8 Cite
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Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Association of Diet Quality with Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events

Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
[JAMA Cardiology]
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Non-Conditioned Bone Marrow Chimeric Mouse Generation Using Culture-Based Enrichment of Hematopoietic Stem and Progenitor Cells

The authors described their development of cell culture techniques for the enrichment of functional hematopoietic stem and progenitor cells from mouse bone marrow without the use of fluorescence-activated cell sorting purification.
[Nature Communications]
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Cryopreservation of Unrelated Donor Hematopoietic Stem Cells: The Right Answer for Transplantations during the COVID-19 Pandemic?

Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.
[Bone Marrow Transplantation]
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60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy

The authors review the historical basis underpinning the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as well as advances in knowledge obtained by defining mechanisms of allo-HSCT activity.
[Cancer Research]
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Bristol Myers Squibb Announces Positive Topline Results from Phase III TRANSFORM Trial Evaluating Breyanzi (lisocabtagene maraleucel) Versus Chemotherapy Followed by Stem Cell Transplant in Second-Line Relapsed or Refractory Large B-cell Lymphoma

Bristol Myers Squibb announced positive results from TRANSFORM, a Phase III study evaluating Breyanzi as a second-line treatment in adults with relapsed or refractory large B-cell lymphoma compared to salvage therapy followed by high-dose chemotherapy and hematopoietic stem cell transplant.
[Bristol Myers Squibb]
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In Vitro Expansion of Fetal Liver Hematopoietic Stem Cells

Scientists explored the expansion of fetal liver hematopoietic stem cells under in vitro conditions. They isolated mononuclear cells from fetal liver and hematopoietic stem cells were identified and analyzed by cell surface marker CD34.
[Scientific Reports]
Bhardwaj, R., Kumar, L., Chhabra, D., Mehra, N. K., Sharma, A., Mohanty, S., & Kochupillai, V. (2021). In vitro expansion of fetal liver hematopoietic stem cells. Scientific Reports, 11(1), 11879. https://doi.org/10.1038/s41598-021-91272-6 Cite
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Prognostic Value of Measurable Residual Disease Monitoring by Next-Generation Sequencing before and after Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia

The authors collected samples before and after allogeneic hematopoietic stem cell transplantation from two independent prospective cohorts and investigated the prognostic impact of amplicon-based next-generation sequencing-based assessment.
[Blood Cancer Journal]
Kim, H.-J., Kim, Y., Kang, D., Kim, H. S., Lee, J.-M., Kim, M., & Cho, B.-S. (2021). Prognostic value of measurable residual disease monitoring by next-generation sequencing before and after allogeneic hematopoietic cell transplantation in acute myeloid leukemia. Blood Cancer Journal, 11(6), 1–11. https://doi.org/10.1038/s41408-021-00500-9 Cite
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