hematopoietic stem cells

[Nature Communications] Investigators showed that inducible CD36 was required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transition from glycolysis towards β-oxidation.

[Molecular Therapy-Methods & Clinical Development] The authors tested a new in vivo hematopoietic stem cell (HSC) transduction/selection approach in rhesus macaques using HSC-tropic, integrating, helper-dependent adenovirus vectors (HDAd5/35++) designed for expression of human γ−globin in red blood cells to treat hemoglobinopathies.

[PLoS Genetics] Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.

[Cancer Letters] OR21 exhibited anti-tumor effects as a monotherapy, and in combination therapy it increased tyrosine kinase inhibitors -induced apoptosis and induction of tumor suppressor genes including PTPN6 encoding SHP-1 in chronic myeloid leukemia cells.

[Molecular Therapy-Methods & Clinical Development] Investigators tested a new in vivo HSC transduction/selection approach in rhesus macaques using HSC-tropic, integrating, helper-dependent adenovirus vectors (HDAd5/35++) designed for expression of human γ−globin in red blood cells to treat hemoglobinopathies.

[Leukemia] The authors highlight accumulating evidence that innate and adaptive immunity modulates several aspects of hematopoiesis within the hormetic zone in which the biological response to low exposure to potential stressors generally is favorable and benefits hematopoietic stem/progenitor cells.