Diaphanous-Related Formin mDia2 Regulates Beta2 Integrins to Control Hematopoietic Stem and Progenitor Cell Engraftment

Scientists showed that loss of diaphanous-related formin mDia2 led to impaired engraftment of long-term hematopoietic stem cells and loss of competitive hematopoietic stem and progenitor cell repopulation.
[Nature Communications]
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Synthetic Lethal Targeting of TET2-Mutant Hematopoietic Stem and Progenitor Cells (HSPCs) with TOP1-Targeted Drugs and PARP1 Inhibitors

Researchers tested 129 FDA-approved anticancer drugs in a tet2-deficient zebrafish model and showed that topoisomerase 1 (TOP1)-targeted drugs and PARP1 inhibitors selectively killed tet2-mutant HSPCs.
[Leukemia]
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Biomimetic Reconstruction of the Hematopoietic Stem Cell Niche for In Vitro Amplification of Human Hematopoietic Stem Cells

To model the natural HSC niche in vitro, researchers optimized the HSC medium composition with a panel of cytokines and valproic acid and used an artificial 3D bone marrow-like scaffold made of polydimethylsiloxane.
[PLoS One]
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Quantitative Proteomics Reveals Specific Metabolic Features of Acute Myeloid Leukemia Stem Cells

By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.
[Blood]
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Anti-Relapse Effects of Donor Natural Killer Cells and IL-2 Gene Modification on Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia

The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
[Cancer Biomarkers]
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Allogeneic Hematopoietic Stem Cell Transplantation from a 2-HLA-Haplotype-Mismatched Family Donor for Posttransplant Relapse: A Prospective Phase I/II Study

In order to explore the possibility of HLA-mismatched hematopoietic stem cell transplantation from family donors beyond haploidentical relatives, the authors conducted a prospective Phase I/II study of 2-HLA-haplotype-mismatched hematopoietic stem cell transplantation (HSCT).
[Bone Marrow Transplantation]
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S100A6 Is a Critical Regulator of Hematopoietic Stem Cells

Researchers showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.
[Leukemia]
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Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
[Stem Cells]
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Risk Score to Predict Event-Free Survival after Hematopoietic Cell Transplant for Sickle Cell Disease

Investigators developed a risk score to predict event-free survival after allogeneic hematopoietic cell transplantation for sickle cell disease.
[Blood]
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MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]
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Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.
[Cancers]
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