hematopoietic stem cells

[Stem Cell Research & Therapy] Bone-associated MSCs (BA-MSCs) were isolated from gene knockout mice, and the effect of Caspase-3/NLRP3 deficient BA-MSCs on hematopoiesis regulation was explored in vivo and ex vivo.

[Stem Cells Translational Medicine] In this review, the gap between the many basic studies and limited clinical trials on stem cell-derived RBCs and platelets is summarized.

[Science Advances] The authors found that HSCs enlarged under conditions known to decrease stem cell function, and concluded that small cell size was important for stem cell function in vivo and proposed that stem cell enlargement contributed to their functional decline during aging.

[Cell Reports Medicine] By combining hematopoietic stem cell (HSC) gene engineering and in vitro differentiation, scientists generated human allogeneic HSC-engineered invariant natural killer T cells at high yield and purity.

[International Journal of Cancer] Investigators introduced a CD33-directed third-generation CAR T cell product for the treatment of patients with acute myeloid leukemia.

[Humanigen, Inc.] Humanigen, Inc. announced it plans to support a Phase II/III study to evaluate lenzilumab for the early treatment of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation in collaboration with IMPACT.