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hematopoietic stem cells

Retrospective Comparison of Hematopoietic Stem Cell Transplantation Following Reduced-Intensity Conditioning with Fludarabine/Low-Dose Melphalan plus 4 Gy TBI versus Fludarabine/ Busulfan plus 4 Gy TBI

[International Journal of Hematology] The authors evaluated the effect of reducing the melphalan dose and retrospectively compared transplant outcomes in 156 patients who received FB2 (n = 103) or FM80 (n = 53) at the center (median age: 63 years; range 27–72 years).

Alemtuzumab Clearance, Lymphocyte Count, and T Cell Chimerism After Hematopoietic Stem Cell Transplant in Sickle Cell Disease

[Pharmacotherapy] Investigators examined the pharmacokinetics and pharmacodynamics of alemtuzumab in adults with sickle cell disease who received a matched related donor hematopoietic stem cell transplant and determined if the clearance of alemtuzumab affected transplant outcomes.

p21-Activated Kinases as Promising Therapeutic Targets in Hematological Malignancies

[Leukemia] The authors review the most recent studies that provide experimental evidence showing how specific p21-activated kinases regulate the properties of leukemic stem cells and drug-resistant cells to initiate and maintain hematological malignancies.

Hematopoietic Stem and Progenitor Cells outside the Bone Marrow: Where, When and Why

[Experimental Hematology] Scientists summarize what is currently known about extramedullary hematopoietic stem and progenitor cells (HSPCs) and extramedullary hematopoiesis in mice and humans.

Cytoplasmic CD79a Is a Promising Biomarker for B Lymphoblastic Leukemia Follow Up Post CD19 CAR-T Therapy

[Leukemia & Lymphoma] Researchers investigated the efficiency and prognostic role of cytoplasmic CD79a antibody-gated multicolor flow cytometry in minimal residual disease detection in patients with B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell therapy bridging to allogeneic hematopoietic stem cell transplantation.

Long-Term Immune Recovery After Hematopoietic Stem Cell Transplantation for ADA Deficiency: a Single-Center Experience

[Journal of Clinical Immunology] The authors found that donor engraftment in the myeloid compartment was significantly diminished in unconditioned procedures, which typically use a HLA-matched sibling donor or family donor.

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