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hematopoietic stem cells
Cancer Stem Cell News
Context-Specific Effects of NOX4 Inactivation in Acute Myeloid Leukemia (AML)
[Journal of Cancer Research and Clinical Oncology] Nox4 inactivation in normal HSCs and progenitor cells caused a minor reduction in HSC numbers and reconstitution capacity.
Hematopoiesis News
Advances in Understanding the Molecular Basis of Clonal Hematopoiesis
[Trends in Molecular Medicine] Investigators review the most recent advances in understanding the molecular basis of clonal hematopoiesis in health and disease.
Hematopoiesis News
Immunological Barriers to Hematopoietic Stem Cell Gene Therapy
[Nature Reviews Immunology] Recent clinical successes for gene therapies involving autologous HSC transplantation demonstrate the potential of genetic engineering in this stem cell type for curing disease.
Hematopoiesis News
Acute Myeloid Leukemia Cells Functionally Compromise Hematopoietic Stem/Progenitor Cells Inhibiting Normal Hematopoiesis through the Release of Extracellular Vesicles
[Frontiers in Oncology] Investigators found that AML cells released a heterogeneous population of extracellular vesicles containing microRNAs involved in AML pathogenesis.
Cancer Stem Cell News
A Self-Assembled Leucine Polymer Sensitizes Leukemic Stem Cells to Chemotherapy by Inhibiting Autophagy in Acute Myeloid Leukemia
[Haematologica] Investigators found that AML cells obtained from relapsed patients had increased autophagy levels than de novo AML cells.
Hematopoiesis News
Hematopoietic Stem Cells Temporally Transition to Thrombopoietin Dependence in the Fetal Liver
[Science Advances] Investigators found that HSCs temporally transitioned to depend on thrombopoietin, a key extrinsic factor, from E16.5 onward in the developing liver.
