hematopoietic stem cells

[IN8bio, Inc.] IN8bio, Inc. announced completion of dosing of the first patient cohort in a Phase I clinical trial of INB-100, a donor-derived gamma-delta T cell therapeutic in development for patients with leukemia undergoing haploidentical stem cell transplant.

[Journal of Allergy and Clinical Immunology] Investigators developed a novel strategy for the rapid and efficient differentiation of mast cells from human iPSCs.

[Nature Communications] Scientists showed that human T cells engineered to express an mLPA-specific TCR, targeted diverse CD1c-expressing leukemia blasts in vitro and significantly delayed the progression of three models of leukemia xenograft in NSG mice, an effect that was boosted by mLPA-cellular immunization.

[Bone Marrow Transplantation] The association between hematopoietic stem-cell transplantation and early- and late-onset cardiotoxicity remains controversial as these cardiac complications, including acute heart failure and arrhythmia, such as atrial fibrillation, can occasionally be lethal.

[Science Advances] Researchers found that the levels of the histone acetyltransferase males absent on the first and its target modification histone H4 lysine 16 acetylation were heterogeneous among HSCs and influenced their proliferation capacities.

[Cell Death & Differentiation] Investigators identified tetraspanin CD63 as a novel functional marker of HSCs in mice and showed that CD63 was unevenly expressed on the cell surface in HSC populations.