hematopoietic stem cells

[Drug Discovery Today] Scientists summarize the targeted therapy approaches for the removal of leukemic stem cells (LSCs) through surface markers including immune checkpoint molecules, pathways influencing LSC survival, or the survival microenvironment of LSCs.

[Nature Cancer] Researchers demonstrated that DNA methyltransferase 3A (DNMT3AR882H)-dependent clonal hematopoiesis and acute myeloid leukemia cells are specifically susceptible to the hypomethylating agent azacytidine.

[Leukemia] The authors studied the impact of pretreatment with JAK1/2 inhibitor ruxolitinib on patient outcome after allogeneic hematopoietic stem cell transplantation.

[Stem Cells] Scientists exposed healthy bone marrow-derived CD34+ hematopoietic stem and progenitor cells (HSPC) to cell-free supernatants derived from acute myeloid leukemia (AML) cell lines to examine proliferation, cell cycling, colony formation, and differentiation of healthy CD34+ HSPC.

[Blood] The authors demonstrated the feasibility of generating CD19-specific chimeric antigen receptor (CAR19) T-cells from HLA-matched donors of sibling allogeneic hematopoietic stem cell transplant patients via a simple and inexpensive method using the piggyBac transposon.

[Archivum Immunologiae Et therapiae Experimentalis] The authors summarize recent advances in knowledge about osteopontin function in the kidney, heart, liver, lung, and hematopoietic stem cell transplantation.