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hematopoietic stem cells

Characterization of Disease-Propagating Stem Cells Responsible for Myeloproliferative Neoplasm-Blast Phase

[JCI Insight] Researchers showed that myeloproliferative neoplasm (MPN)-blast phase (BP) initiating cells originated from not only phenotypically identified hematopoietic stem cells but also lymphoid-myeloid progenitor cells which were each characterized by differences in MPN-BP initiating activity and self-renewal capacity.

Identification of the Global miR-130a Targetome Reveals a Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8; 21) AML

[Cell Reports] Investigators established that identification of the comprehensive miRNA targetome within primary cells enabled discovery of genes and molecular networks underpinning stemness properties of normal and leukemic cells.

Revisiting Hematopoiesis: Applications of the Bulk and Single-Cell Transcriptomics Dissecting Transcriptional Heterogeneity in Hematopoietic Stem Cells

[Briefings in Functional Genomics] The authors discuss the recent findings and computational methods used to unravel the new HSC model revise over the classical model.

Genetic Correction of Concurrent α- and β-Thalassemia Patient-Derived Pluripotent Stem Cells by the CRISPR-Cas9 Technology

[Stem Cell Research & Therapy] The authors established a new hiPSCs line derived from amniotic cells of a fetus with a homozygous β41-42 deletion mutation in the HBB gene and a heterozygous Westmead mutation in the HBA2 gene. They designed a CRISPR-Cas9 to target these casual mutations and corrected them.

Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia

[Cancer Immunology Research] Researchers tested the in vitro effect of different natural killer (NK)-cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and targeted either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.

Tet-Mediated DNA Demethylation Regulates Specification of Hematopoietic Stem and Progenitor Cells during Mammalian Embryogenesis

[Science Advances] Scientists found that global or endothelial-specific loss of all three Tet enzymes immediately after gastrulation led to a reduced number of HSCs and progenitor cells and lethality in mid-gestation mouse embryos.

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