Tag results:
hematopoietic stem cells
Hematopoiesis News
Characterization of Disease-Propagating Stem Cells Responsible for Myeloproliferative Neoplasm-Blast Phase
[JCI Insight] Researchers showed that myeloproliferative neoplasm (MPN)-blast phase (BP) initiating cells originated from not only phenotypically identified hematopoietic stem cells but also lymphoid-myeloid progenitor cells which were each characterized by differences in MPN-BP initiating activity and self-renewal capacity.
Hematopoiesis News
Identification of the Global miR-130a Targetome Reveals a Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8; 21) AML
[Cell Reports] Investigators established that identification of the comprehensive miRNA targetome within primary cells enabled discovery of genes and molecular networks underpinning stemness properties of normal and leukemic cells.
Hematopoiesis News
Revisiting Hematopoiesis: Applications of the Bulk and Single-Cell Transcriptomics Dissecting Transcriptional Heterogeneity in Hematopoietic Stem Cells
[Briefings in Functional Genomics] The authors discuss the recent findings and computational methods used to unravel the new HSC model revise over the classical model.
ESC & iPSC News
Genetic Correction of Concurrent α- and β-Thalassemia Patient-Derived Pluripotent Stem Cells by the CRISPR-Cas9 Technology
[Stem Cell Research & Therapy] The authors established a new hiPSCs line derived from amniotic cells of a fetus with a homozygous β41-42 deletion mutation in the HBB gene and a heterozygous Westmead mutation in the HBA2 gene. They designed a CRISPR-Cas9 to target these casual mutations and corrected them.
Hematopoiesis News
Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia
[Cancer Immunology Research] Researchers tested the in vitro effect of different natural killer (NK)-cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and targeted either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.
Hematopoiesis News
Tet-Mediated DNA Demethylation Regulates Specification of Hematopoietic Stem and Progenitor Cells during Mammalian Embryogenesis
[Science Advances] Scientists found that global or endothelial-specific loss of all three Tet enzymes immediately after gastrulation led to a reduced number of HSCs and progenitor cells and lethality in mid-gestation mouse embryos.