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hepatic cells

CD116+ Fetal Precursors Migrate to the Perinatal Lung and Give Rise to Human Alveolar Macrophages

[Journal of Experimental Medicine] Scientists identified alveolar macrophage progenitors in human fetal liver that expressed the GM-CSF receptor CD116 and the transcription factor MYB.

Spatial Proteogenomics Reveals Distinct and Evolutionarily Conserved Hepatic Macrophage Niches

[Cell] By integrating multi-omic datasets, investigators provided validated strategies to reliably discriminate and localize all hepatic cells, including a population of lipid-associated macrophages at the bile ducts.

Novartis Announces Collaboration with Alnylam to Explore Targeted Therapy to Restore Liver Function

[Novartis] Novartis announced a collaboration with Alnylam to leverage Alnylam’s proprietary siRNA technology to inhibit a target discovered at the Novartis Institutes for BioMedical Research, potentially leading to development of a treatment designed to promote the regrowth of functional liver cells and to provide an alternative to transplantation for patients with liver failure.

Nano Delivery of Simvastatin Targets Liver Sinusoidal Endothelial Cells to Remodel Tumor Microenvironment for Hepatocellular Carcinoma

[Journal of Nanobiotechnology] The effect of simvastatin on liver sinusoidal endothelial cells and hepatic stellate cells was examined by immunoblotting, quantitative RT-PCR and RNA-seq.

DRAM1 Increases the Secretion of PKM2-Enriched Extracellular Vesicles from Hepatocytes to Promote Macrophage Activation and Disease Progression in Alcohol-Related Liver Disease

[Molecular Therapy-Nucleic Acids] The authors explored the expression, role and mechanism of DNA damage regulated autophagy modulator 1 (DRAM1) in alcohol-related liver disease and revealed that ethanol-induced DRAM1 of hepatic cells could increase the pyruvate kinase M2 (PKM2)-enriched extracellular vesicles.

Identification of Gm15441, a Txnip Antisense lncRNA, as a Critical Regulator in Liver Metabolic Homeostasis

[Cell & Bioscience] Scientists investigated the role of Gm15441 in the regulation of thioredoxin-interacting protein (Txnip) and liver metabolism and found that the expression levels of Gm15441 and Txnip showed a similar response pattern to metabolic signals in vivo and in vitro, but that their functions were predicted to be opposite.

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