Tag results:
hepatic cells
Hepatic Cell News
A 3D Primary Human Cell-Based In Vitro Model of Non-Alcoholic Steatohepatitis for Efficacy Testing of Clinical Drug Candidates
[Scientific Reports] Investigators presented a 3D in vitro microtissue model that used spheroidal, scaffold free co-culture of primary human hepatocytes, Kupffer cells, liver endothelial cells and hepatic stellate cells.
Hepatic Cell News
STING Signaling Activation Inhibits HBV Replication and Attenuates the Severity of Liver Injury and HBV-Induced Fibrosis
[Cellular & Molecular Immunology] Agonist-induced stimulator of interferon genes (STING) signaling activation in macrophages was revealed to inhibit covalently closed circular DNA-mediated transcription and hepatitis B virus (HBV) replication via epigenetic modification in hepatocytes.
Hepatic Cell News
Plasmodium Sporozoite Phospholipid Scramblase Interacts with Mammalian Carbamoyl-Phosphate Synthetase 1 to Infect Hepatocytes
[Nature Communications] Investigators screened a phage display library for peptides that structurally mimicked a sporozoite ligand for hepatocyte recognition.
Hepatic Cell News
Yap-Sox9 Signaling Determines Hepatocyte Plasticity and Lineage-Specific Hepatocarcinogenesis
[Journal of Hepatology] Scientists investigated the role of Sox9, a transcription factor downstream of Yap activation and expressed in biliary epithelial cells (BECs), in Yap-induced cell fate plasticity during hepatocarcinogenesis.
Hepatic Cell News
A New Perspective on NAFLD: Focusing on Lipid Droplets
[Journal of Hepatology] Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.
Hepatic Cell News
Thyroid Hormone Signaling Promotes Hepatic Lipogenesis through the Transcription Factor ChREBP
[Science Signaling] TRβ1 and its principal corepressor NCoR1 in hepatocytes repressed de novo lipogenesis, whereas the TH-mediated induction of lipogenic genes depended on the transcription factor ChREBP.