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hepatic cells

A 3D Primary Human Cell-Based In Vitro Model of Non-Alcoholic Steatohepatitis for Efficacy Testing of Clinical Drug Candidates

[Scientific Reports] Investigators presented a 3D in vitro microtissue model that used spheroidal, scaffold free co-culture of primary human hepatocytes, Kupffer cells, liver endothelial cells and hepatic stellate cells.

STING Signaling Activation Inhibits HBV Replication and Attenuates the Severity of Liver Injury and HBV-Induced Fibrosis

[Cellular & Molecular Immunology] Agonist-induced stimulator of interferon genes (STING) signaling activation in macrophages was revealed to inhibit covalently closed circular DNA-mediated transcription and hepatitis B virus (HBV) replication via epigenetic modification in hepatocytes.

Plasmodium Sporozoite Phospholipid Scramblase Interacts with Mammalian Carbamoyl-Phosphate Synthetase 1 to Infect Hepatocytes

[Nature Communications] Investigators screened a phage display library for peptides that structurally mimicked a sporozoite ligand for hepatocyte recognition.

Yap-Sox9 Signaling Determines Hepatocyte Plasticity and Lineage-Specific Hepatocarcinogenesis

[Journal of Hepatology] Scientists investigated the role of Sox9, a transcription factor downstream of Yap activation and expressed in biliary epithelial cells (BECs), in Yap-induced cell fate plasticity during hepatocarcinogenesis.

A New Perspective on NAFLD: Focusing on Lipid Droplets

[Journal of Hepatology] Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.

Thyroid Hormone Signaling Promotes Hepatic Lipogenesis through the Transcription Factor ChREBP

[Science Signaling] TRβ1 and its principal corepressor NCoR1 in hepatocytes repressed de novo lipogenesis, whereas the TH-mediated induction of lipogenic genes depended on the transcription factor ChREBP.

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