hepatic stellate cells

[Pharmacology & Therapeutics] The authors summarize the regulating mechanisms of autophagy through different targets and signal pathways in energy metabolism-related hepatic fibrosis, and discuss the regulatory effect of autophagy by natural plant-derived, endogenous and synthetic compounds for the treatment of hepatic fibrosis.

[Advanced Materials] The authors systemically review the diverse interactions of nanomaterials with the liver, specifically on major liver cell types including Kupffer cells, liver sinusoidal endothelial cells, hepatic stellate cells, and hepatocytes as well as the detailed molecular mechanisms involved.

[Acta Pharmacologica Sinica] Researchers investigated whether tetramethylpyrazine exerted liver-protective action through regulating extracellular vesicle-dependent intercellular communication between hepatocytes and hepatic stellate cells.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Investigators revealed a continuous signaling pathway, MAPK p38-Ulk1 phosphorylation-Ulk1/Atg13 disruption, which inhibited autophagy and induced IL-1β expression in hepatic stellate cells.

[Cell] By integrating multi-omic datasets, investigators provided validated strategies to reliably discriminate and localize all hepatic cells, including a population of lipid-associated macrophages at the bile ducts.

[Journal of Nanobiotechnology] The effect of simvastatin on liver sinusoidal endothelial cells and hepatic stellate cells was examined by immunoblotting, quantitative RT-PCR and RNA-seq.