hepatic stellate cells

[iScience] To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes across different nonalcoholic fatty liver disease stages were profiled, identifying hepatocytes and 12 other non-parenchymal cell types.

[Stem Cells and Development] Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.

[Scientific Reports] Researchers investigated the effect of differential expression of CYP2R1 in hepatocytes on the expression of genes related to liver fibrosis in primary hepatic stellate cells of biliary atresia and animal models of cholestasis.

[Scientific Reports] Scientists profiled 17,810 non-parenchymal cells derived from six healthy human livers, which enabled the identification of potential intercellular signaling axes and master regulators responsible for the activation of hepatic stellate cells during fibrogenesis.

[Journal of Gastroenterology and Hepatology] The authors aimed to evaluate the role of O-GlcNAc transferase (OGT) in hepatic stellate cells (HSCs) and its consequent role in liver fibrosis. RNA-seq showed that OGT knockdown in HSCs modulated key signaling pathways involved in HSC activation.

[Cancer Research] Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.