hepatocytes

[Cell Death & Disease] To address the effect of Arid1a deficiency on chromatin organization, investigators generated chromatin interaction matrices, and exploited the conformation changes upon Arid1a depletion in hepatocytes.

[Cell Death & Disease] Centrosomal P4.1-associated protein (CPAP) could increase the expression of chemokine ligand 16 (CCL-16), an important chemotactic cytokine in human hepatocytes. CCL-16 expression was positively correlated with CPAP and TNF-α mRNA expression in the peritumoral part of hepatocellular carcinoma.

[Stem Cell Reports] The authors review proposed mutations in the recipient embryo to disable hepatogenesis, and discuss the advantages of using fumarylacetoacetate hydrolase knockouts and other genetic modifications to disable hepatogenesis.

[Experimental & Molecular Medicine] The authors describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo.

[Journal of Physiology and Biochemistry] Researchers proved that estrogen had a protective effect on both hepatocyte hypoxia re-oxygen challenge and mouse hepatic ischemia reperfusion model.

[Stem Cell Reports] TBX3 mutant human PSC lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregulation of pancreatic gene expression, including PDX1, during a hepatocyte differentiation protocol.