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hepatocytes

In Vitro Culture at 39 °C during Hepatic Maturation of Human ES Cells Facilitates Hepatocyte-Like Cell Functions

[Scientific Reports] Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.

HNF4A-AS1-Encoded Small Peptide Promotes Self-Renewal and Aggressiveness of Neuroblastoma Stem Cells via eEF1A1-Repressed SMAD4 Transactivation

[Oncogene] The authors suggested that hepatocyte nuclear factor 4 alpha antisense RNA 1 (HNF4A-AS1)-encoded small 51-amino acid peptide promoted self-renewal and aggressive features of neuroblastoma stem cells by eEF1A1-repressed SMAD family member 4 (SMAD4) transactivation.

The Vesicular Transporter STX11 Governs ATGL-Mediated Hepatic Lipolysis and Lipophagy

[iScience] Scientists demonstrated that syntaxin11 (STX11), a member of the SNARE family, generally expressed in immune cells, mediated lipid metabolism by binding to adipose-triglyceride-lipase (ATGL) and inhibiting lipid droplet degradation and lipid autophagy in hepatocytes.

Vertebrate Lonesome Kinase Modulates the Hepatocyte Secretome to Prevent Perivascular Liver Fibrosis and Inflammation

[Journal of Cell Science] Cultured progenitor cells established from primary hepatocytes of Pkdcc knockout mice produced a secretome, which promoted their own proliferation in 3D spheroids and proliferation of cultured fibroblasts.

Role of XBP1 in Regulating the Progression of Non-alcoholic Steatohepatitis

[Journal of Hepatology] Researchers investigated the role of X-box binding protein-1 (XBP1) in the progression of non-alcoholic steatohepatitis.

Transmembrane Channel Activity in Human Hepatocytes and Cholangiocytes Derived from Induced Pluripotent Stem Cells

[Hepatology Communications] Researchers generated iPSC-derived hepatocytes and iPSC-derived cholangiocytes cells and characterized them based on hepatocyte-specific and cholangiocyte-specific markers.

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