Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
[zotpress userid=” items=’GPARQPAM’ style=’apa’ cite=’yes’]
Scientists found the NEU4 expression was significantly down-regulated in hepatocellular carcinoma (HCC) tissues, which was correlated with high grades and poor outcomes of HCC.
[zotpress userid=” items=’E4EA5H99′ style=’apa’ cite=’yes’]
Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
[zotpress userid=’6445218′ items=’SPGJUG6Q’ style=’apa’ cite=’yes’]
Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.
[Journal of Clinical Investigation]
[zotpress userid=’6445218′ items=’AAW2GWZV’ style=’apa’ cite=’yes’]
Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
[zotpress userid=” items=’UI9ND885′ style=’apa’ cite=’yes’]
Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.
[zotpress userid=’7753456′ items=’F6CPJQNV’ style=’apa’ cite=’yes’]
Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
[zotpress userid=” items=’AR6SQIIF’ style=’apa’ cite=’yes’]
Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.
[Cell Death Discovery]
[zotpress userid=’6807162′ items=’VWVHCE6K’ style=’apa’ cite=’yes’]
The authors showed in prostate cancer cells that arginine acted as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes.
[zotpress userid=’6807162′ items=’9YSXCZKP’ style=’apa’ cite=’yes’]
Scientists report that a p300/CBP inhibitor, A-485, could overcome resistance to idelalisib in mantle cell lymphoma cells in vitro and in vivo.
[Acta Pharmacologica Sinica]
[zotpress userid=’6445212′ items=’SBHNB93Q’ style=’apa’ cite=’yes’]
Two kinds of Wharton’s jelly-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with intrauterine growth retardation (IUGR) and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR newborns.
[Stem Cell Research & Therapy]
[zotpress userid=’6445212′ items=’BSWPHZIN’ style=’apa’ cite=’yes’]