Bromodomain-Containing Protein BRPF1 Is a Therapeutic Target for Liver Cancer

Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
[Communications Biology]
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NEU4 Inhibits Motility of HCC Cells by Cleaving Sialic Acids on CD44

Scientists found the NEU4 expression was significantly down-regulated in hepatocellular carcinoma (HCC) tissues, which was correlated with high grades and poor outcomes of HCC.
[Oncogene]
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TCF1 in T Cell Immunity: A Broadened Frontier

Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
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Histone Deficiency and Accelerated Replication Stress in T Cell Aging

Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.
[Journal of Clinical Investigation]
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Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation

Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
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C646 Inhibits G2/M Cell Cycle-Related Proteins and Potentiates Anti-Tumor Effects in Pancreatic Cancer

Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.
[Scientific Reports]
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Targeting Epigenetic and Post-Transcriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth

Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
[Cancer Research]
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Histone Modifications Centric-Regulation in Osteogenic Differentiation

Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.
[Cell Death Discovery]
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Arginine Is an Epigenetic Regulator Targeting TEAD4 to Modulate OXPHOS in Prostate Cancer Cells

The authors showed in prostate cancer cells that arginine acted as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes.
[Nature Communications]
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P300/CBP Inhibition Sensitizes Mantle Cell Lymphoma to PI3Kδ Inhibitor Idelalisib

Scientists report that a p300/CBP inhibitor, A-485, could overcome resistance to idelalisib in mantle cell lymphoma cells in vitro and in vivo.
[Acta Pharmacologica Sinica]
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H3K9ac of TGFβRI in Human Umbilical Cord: A Potential Biomarker for Evaluating Cartilage Differentiation and Susceptibility to Osteoarthritis via a Two-Step Strategy

Two kinds of Wharton’s jelly-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with intrauterine growth retardation (IUGR) and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR newborns.
[Stem Cell Research & Therapy]
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