histone acetylation

[Nature Communications] Transcriptional profiling and in vitro assays using human melanoma cells demonstrated that SALL4 loss induced a phenotype switch and the acquisition of an invasive phenotype.

[British Journal of Cancer] The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.

[Communications Biology] Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.

[Oncogene] Scientists found the NEU4 expression was significantly down-regulated in hepatocellular carcinoma (HCC) tissues, which was correlated with high grades and poor outcomes of HCC.

[Nature Reviews Immunology] Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.

[Journal of Clinical Investigation] Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.